ArticleFrontiers in neuroscience2016
Altered Onset Response Dynamics in Somatosensory Processing in Autism Spectrum Disorder.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical Auditory Processing of Simple Stimuli Is Altered in Autism: A Meta-analysis of Auditory Evoked Responses.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Pooled it
- Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Cortical signatures of auditory object binding in children with autism spectrum disorder are anomalous in concordance with behavior and diagnosis.PLoS biology · 2022Article
- Region-specific elevations of glutamate + glutamine correlate with the sensory symptoms of autism spectrum disorders.Translational psychiatry · 2021Article
- Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum.Molecular autism · 2021Article
- Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder.Journal of neurodevelopmental disorders · 2021Article
- Article
- Towards a Multivariate Biomarker-Based Diagnosis of Autism Spectrum Disorder: Review and Discussion of Recent Advancements.Seminars in pediatric neurology · 2020Review
- Permutation Statistics for Connectivity Analysis between Regions of Interest in EEG and MEG Data.Scientific reports · 2019Article
- Maturational trajectories of local and long-range functional connectivity in autism during face processing.Human brain mapping · 2018Article
- Prenatal Valproate Exposure Differentially Affects Parvalbumin-Expressing Neurons and Related Circuits in the Cortex and Striatum of Mice.Frontiers in molecular neuroscience · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Abnormalities in cortical connectivity and evoked responses have been extensively documented in autism spectrum disorder (ASD). However, specific signatures of these cortical abnormalities remain elusive, with data pointing toward abnormal patterns of both increased and reduced response amplitudes and functional connectivity. We have previously proposed, using magnetoencephalography (MEG) data, that apparent inconsistencies in prior studies could be reconciled if functional connectivity in ASD was reduced in the feedback (top-down) direction, but increased in the feedforward (bottom-up) direction. Here, we continue this line of investigation by assessing abnormalities restricted to the onset, feedforward inputs driven, component of the response to vibrotactile stimuli in somatosensory cortex in ASD. Using a novel method that measures the spatio-temporal divergence of cortical activation, we found that relative to typically developing participants, the ASD group was characterized by an increase in the initial onset component of the cortical response, and a faster spread of local activity. Given the early time window, the results could be interpreted as increased thalamocortical feedforward connectivity in ASD, and offer a plausible mechanism for the previously observed increased response variability in ASD, as well as for the commonly observed behaviorally measured tactile processing abnormalities associated with the disorder.
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Registered trials
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