Evidence map›Paper›PMID 27375360›Full record

ArticleNutrition and metabolic insights2016

Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury.

Janelle L Davis, Hunter L Paris, Joseph W Beals, Scott E Binns, Gregory R Giordano, Rebecca L Scalzo, Melani M Schweder, Emek Blair, Christopher Bell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and metabolic insights, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 82 citations in OpenAlex.

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  12. Targeted nanoliposomal nutrient delivery for human health.World journal of gastrointestinal pharmacology and therapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Janelle L DavisDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Hunter L ParisDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Joseph W BealsDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Scott E BinnsDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Gregory R GiordanoDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Rebecca L ScalzoDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Melani M SchwederDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Emek BlairEmpirical Labs, Fort Collins, Colorado, USA.; Nutritional Biomimetics LLC, Fort Collins, Colorado, USA.; Present address: Valimenta Labs, Fort Collins, Colorado, USA.
Christopher BellDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Colorado State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous administration of vitamin C has been shown to decrease oxidative stress and, in some instances, improve physiological function in adult humans. Oral vitamin C administration is typically less effective than intravenous, due in part to inferior vitamin C bioavailability. The purpose of this study was to determine the efficacy of oral delivery of vitamin C encapsulated in liposomes. On 4 separate randomly ordered occasions, 11 men and women were administered an oral placebo, or 4 g of vitamin C via oral, oral liposomal, or intravenous delivery. The data indicate that oral delivery of 4 g of vitamin C encapsulated in liposomes (1) produces circulating concentrations of vitamin C that are greater than unencapsulated oral but less than intravenous administration and (2) provides protection from ischemia-reperfusion-mediated oxidative stress that is similar to the protection provided by unencapsulated oral and intravenous administrations.

Indexed as

intravenousliposomeoraloxidative stressthiobarbituric acid reactive substances

Identifiers

PMID27375360
PMCPMC4915787
OpenAlexW2472818278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.