Evidence map›Paper›PMID 27375237›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2016

Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment.

Xu Wang, Alexa Bodman, Changying Shi, Dandan Guo, Lili Wang, Juntao Luo, Walter A Hall

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xu WangDepartment of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Alexa BodmanDepartment of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Changying ShiDepartment of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Dandan GuoDepartment of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Lili WangDepartment of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Juntao LuoDepartment of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Walter A HallDepartment of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.

Funding

Size-tunable cancer nanotherapeuticsR01CA140449 · NCI · UPSTATE MEDICAL UNIVERSITY · PI LUO, JUNTAO · 2010 to 2014
$1.6M
An innovative hemoperfusion nanotrap for sepsis treatment.R01GM130941 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI LUO, JUNTAO · 2018 to 2021
$1.5M
Rational Design and High throughput synthesis of nanocarriers for efficient drug deliveryR21EB019607 · NIBIB · UPSTATE MEDICAL UNIVERSITY · PI LUO, JUNTAO · 2015 to 2016
$453k
NCI NIH HHS R01 CA140449NIBIB NIH HHS R21 EB019607
6 · The paper itself

Abstract

A strategy to precisely engineer lipidoid-telodendrimer binary hybrid nanoparticles that offer enhanced cell membrane permeability for therapeutic proteins to reach the intracellular targets is established. The highly controllable biochemical and physical properties of the nanoparticles make them promising for protein-based brain cancer treatment with the assistance of convection-enhanced delivery.

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorHumansLipidsModels, TheoreticalNanoparticlesProteinsLipidsProteinsglioblastomalipidoidsnanoparticlesprotein deliverytelodendrimers

Identifiers

PMID27375237
PMCPMC4982832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.