Mechanisms of Acetaminophen Hepatotoxicity: Do We Need JNK for Cell Death?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

5 citing papers in PubMed.

1. Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.Journal of the American Society for Mass Spectrometry · 2022
   Article
2. A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.Scientific reports · 2019
   Article
3. New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases.Hepatology (Baltimore, Md.) · 2018
   Review
4. Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity.Frontiers in pharmacology · 2018
   Review
5. AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function.PloS one · 2016
   Article

Corrections and comments

• Commented on by
  Reply.2016
• Comment on
  Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.2016

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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