Evidence map›Paper›PMID 27374990›Full record

ReviewBiochimica et biophysica acta2016

NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy.

Yue Yang, Anthony A Sauve

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03642990 (Nicotinamide Riboside), which is not on this map. Cited by 271 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed, 1 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03642990 phase2terminatednot on this mapstarted 2019, after this paper: background citation

Nicotinamide Riboside (NR) in Paclitaxel-induced Peripheral Neuropathy

TypeinterventionalSponsorDonna Hammond, PhDRan2019 to 2022Enrolled5ConditionsChemotherapy-induced Peripheral Neuropathy, Breast Cancer Metastatic, Platinum-resistant Recurrent Ovarian Cancer, Head and Neck Cancer Stage IVArmsNicotinamide Riboside
3 · Its place in the literature

Who cites it

271 citing papers in PubMed, 1 synthesis or guideline pooled it, 480 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. NADInternational journal of molecular sciences · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

211 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yue YangDepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
Anthony A SauveDepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. Electronic address: aas2004@med.cornell.edu.
Cornell University · US

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Nicotinamide Riboside and NAD+: Modulation of Sirtuins and Reactive OxygenR01GM106072 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAUVE, ANTHONY A. · 2013 to 2016
$1.3M
Chemical Tools to Visualize Sirtuin Activity in CellsR21DK094001 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAUVE, ANTHONY A. · 2012 to 2013
$459k
NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R21 DK094001NIGMS NIH HHS R01 GM106072
6 · The paper itself

Abstract

We survey the historical development of scientific knowledge surrounding Vitamin B3, and describe the active metabolite forms of Vitamin B3, the pyridine dinucleotides NAD

Indexed as

AnimalsEnergy MetabolismHumansMetabolic DiseasesMetabolic Networks and PathwaysModels, BiologicalNADNADPNiacinNiacinamideNucleosidesSignal TransductionSirtuinsTryptophanNADNADPNiacinNiacinamideNucleosidesSirtuinsTryptophanNADHNicotinamide adenine dinucleotideNicotinamide ribosideNicotinic acid ribosideTryptophanVitamin B3

Identifiers

PMID27374990
PMCPMC5521000
OpenAlexW2470982690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.