Evidence map›Paper›PMID 27374875›Full record

ArticleScientific reports2016

Application of flat panel OLED display technology for the point-of-care detection of circulating cancer biomarkers.

Benjamin A Katchman, Joseph T Smith, Uwadiae Obahiagbon, Sailaja Kesiraju, Yong-Kyun Lee, Barry O'Brien, Korhan Kaftanoglu, Jennifer Blain Christen, Karen S Anderson

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin A KatchmanCenter for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281 USA.
Joseph T SmithFlexible Electronics and Display Center at Arizona State University, Tempe, AZ 85284 USA.
Uwadiae ObahiagbonSchool of Electrical Engineering at Arizona State University, Tempe, AZ 85281 USA.
Sailaja KesirajuCenter for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281 USA.
Yong-Kyun LeeFlexible Electronics and Display Center at Arizona State University, Tempe, AZ 85284 USA.
Barry O'BrienFlexible Electronics and Display Center at Arizona State University, Tempe, AZ 85284 USA.
Korhan KaftanogluFlexible Electronics and Display Center at Arizona State University, Tempe, AZ 85284 USA.
Jennifer Blain ChristenSchool of Electrical Engineering at Arizona State University, Tempe, AZ 85281 USA.
Karen S AndersonCenter for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281 USA.

Funding

Biomarker Detection Using NAPPA Tumor Antigen ArraysU01CA117374 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ANDERSON, KAREN SUE, LABAER, JOSHUA · 2005 to 2015
$6.2M
NCI NIH HHS U01 CA117374
6 · The paper itself

Abstract

Point-of-care molecular diagnostics can provide efficient and cost-effective medical care, and they have the potential to fundamentally change our approach to global health. However, most existing approaches are not scalable to include multiple biomarkers. As a solution, we have combined commercial flat panel OLED display technology with protein microarray technology to enable high-density fluorescent, programmable, multiplexed biorecognition in a compact and disposable configuration with clinical-level sensitivity. Our approach leverages advances in commercial display technology to reduce pre-functionalized biosensor substrate costs to pennies per cm(2). Here, we demonstrate quantitative detection of IgG antibodies to multiple viral antigens in patient serum samples with detection limits for human IgG in the 10 pg/mL range. We also demonstrate multiplexed detection of antibodies to the HPV16 proteins E2, E6, and E7, which are circulating biomarkers for cervical as well as head and neck cancers.

Indexed as

AntibodiesBiomarkers, TumorBiosensing TechniquesDNA-Binding ProteinsFemaleHuman papillomavirus 16HumansImmunoglobulin GLimit of DetectionOncogene Proteins, ViralPapillomavirus E7 ProteinsPapillomavirus InfectionsPathology, MolecularPoint-of-Care SystemsProtein Array AnalysisRepressor ProteinsAntibodiesBiomarkers, TumorDNA-Binding ProteinsE2 protein, Human papillomavirus type 16E6 protein, Human papillomavirus type 16Immunoglobulin Goncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsRepressor Proteins

Identifiers

PMID27374875
PMCPMC4931450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.