Evidence map›Paper›PMID 27374794›Full record

ArticleCellular & molecular immunology2017

BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway.

Ran Zhao, Yukun Liu, Heran Wang, Jing Yang, Weihong Niu, Songqing Fan, Wei Xiong, Jian Ma, Xiaoling Li, Joshua B Phillips and 4 more

Open access · greenAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 47 citations in OpenAlex.

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  16. Emerging Roles of BRD7 in Pathophysiology.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Ran ZhaoXiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yukun LiuCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Heran WangCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Jing YangCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Weihong NiuCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Songqing FanThe Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Wei XiongCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Jian MaCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Xiaoling LiCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Joshua B PhillipsMitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
Ming TanMitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
Yuanzheng QiuXiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Guiyuan LiCancer Research Institute, Central South University, Changsha, Hunan 410078, China.
Ming ZhouXiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Central South University · CNMinistry of Education of the People's Republic of China · CNUniversity of South Alabama · USSecond Xiangya Hospital of Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence has shown a strong association between tumor-suppressor genes and inflammation. However, the role of BRD7 as a novel tumor suppressor in inflammation remains unknown. In this study, by observing BRD7 knockout mice for 6-12 months, we discovered that compared with BRD7

Indexed as

AnimalsBromodomain Containing ProteinsCells, CulturedChemokine CXCL1Chromosomal Proteins, Non-HistoneColitisDextran SulfateFibroblastsInflammationInterleukin-6LipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IISignal TransductionBrd7 protein, mouseBromodomain Containing ProteinsChemokine CXCL1Chromosomal Proteins, Non-HistoneCxcl1 protein, mouseDextran SulfateInterleukin-6LipopolysaccharidesNitric Oxide Synthase Type IINos2 protein, mouseRela protein, mouseTranscription Factor RelATumor Necrosis Factor-alpha

Identifiers

PMID27374794
PMCPMC5649105
OpenAlexW2465324490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.