ArticleAmerican journal of human genetics2016
PADRE: Pedigree-Aware Distant-Relationship Estimation.
Article in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- DRIVE v3: Command Line Application for Identity-by-Descent Haplotype Clustering in Large Biobank Scale Data.Genetic epidemiology · 2026Article
- Artificial intelligence enables scale, consistency, and rigor in forensic identity inference.Croatian medical journal · 2026Review
- COMPADRE: Combined pedigree-aware distant relatedness estimation for improved pedigree reconstruction.American journal of human genetics · 2025Article
- Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM.Cell genomics · 2025Article
- A likelihood ratio framework for inferring close kinship from dynamically selected SNPs.Frontiers in genetics · 2025Article
- CORRECTING MODEL MISSPECIFICATION IN RELATIONSHIP ESTIMATES.bioRxiv : the preprint server for biology · 2024Article
- Detection of distant relatedness in biobanks to identify undiagnosed cases of Mendelian disease as applied to Long QT syndrome.Nature communications · 2024Article
- Supporting the use of genetic genealogy in restoring family narratives following the transatlantic slave trade.American anthropologist · 2024Article
- A cost-benefit analysis for use of large SNP panels and high throughput typing for forensic investigative genetic genealogy.International journal of legal medicine · 2023Article
- Evaluating the utility of identity-by-descent segment numbers for relatedness inference via information theory and classification.G3 (Bethesda, Md.) · 2022Article
- Evaluating the Impact of Dropout and Genotyping Error on SNP-Based Kinship Analysis With Forensic Samples.Frontiers in genetics · 2022Article
- Phenome risk classification enables phenotypic imputation and gene discovery in developmental stuttering.American journal of human genetics · 2021Article
- Bonsai: An efficient method for inferring large human pedigrees from genotype data.American journal of human genetics · 2021Article
- The use of shared haplotype length information for pedigree reconstruction in asexually propagated outbreeding crops, demonstrated for apple and sweet cherry.Horticulture research · 2021Article
- Recommendations for Statistical Reporting in Cardiovascular Medicine: A Special Report From the American Heart Association.Circulation · 2021Review
- Pedigree reconstruction and distant pairwise relatedness estimation from genome sequence data: A demonstration in a population of rhesus macaques (Macaca mulatta).Molecular ecology resources · 2021Article
- Dynamics of a Dual SARS-CoV-2 Lineage Co-Infection on a Prolonged Viral Shedding COVID-19 Case: Insights into Clinical Severity and Disease Duration.Microorganisms · 2021Article
- Distinguishing pedigree relationships via multi-way identity by descent sharing and sex-specific genetic maps.American journal of human genetics · 2021Article
- Alternative Applications of Genotyping Array Data Using Multivariant Methods.Trends in genetics : TIG · 2020Review
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Authors and funding
7 authors.
Funding
Abstract
Accurate estimation of shared ancestry is an important component of many genetic studies; current prediction tools accurately estimate pairwise genetic relationships up to the ninth degree. Pedigree-aware distant-relationship estimation (PADRE) combines relationship likelihoods generated by estimation of recent shared ancestry (ERSA) with likelihoods from family networks reconstructed by pedigree reconstruction and identification of a maximum unrelated set (PRIMUS), improving the power to detect distant relationships between pedigrees. Using PADRE, we estimated relationships from simulated pedigrees and three extended pedigrees, correctly predicting 20% more fourth- through ninth-degree simulated relationships than when using ERSA alone. By leveraging pedigree information, PADRE can even identify genealogical relationships between individuals who are genetically unrelated. For example, although 95% of 13(th)-degree relatives are genetically unrelated, in simulations, PADRE correctly predicted 50% of 13(th)-degree relationships to within one degree of relatedness. The improvement in prediction accuracy was consistent between simulated and actual pedigrees. We also applied PADRE to the HapMap3 CEU samples and report new cryptic relationships and validation of previously described relationships between families. PADRE greatly expands the range of relationships that can be estimated by using genetic data in pedigrees.
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Registered trials
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