ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2016
Correlation between genome reduction and bacterial growth.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Growth dynamics of 3,909 Escherichia coli single-gene knockouts in rich and minimal media.Scientific data · 2026Article
- Time Series Data Mining for Linking the Shape of Bacterial Growth Curves to Biological Functions.Computational and structural biotechnology journal · 2026Article
- Data-driven analysis reveals distinct genomic and environmental contributions to bacterial growth curves.Scientific reports · 2025Article
- Data-driven discovery of the interplay between genetic and environmental factors in bacterial growth.Communications biology · 2024Article
- Article
- Enhanced protein secretion in reduced genome strains of Streptomyces lividans.Microbial cell factories · 2024Article
- Review
- Environmental Adaptation of Psychrophilic Bacteria Subtercola spp. Isolated from Various Cryospheric Habitats.Journal of microbiology (Seoul, Korea) · 2023Article
- Article
- Article
- Greedy reduction of Bacillus subtilis genome yields emergent phenotypes of high resistance to a DNA damaging agent and low evolvability.Nucleic acids research · 2023Article
- Growth rate-associated transcriptome reorganization in response to genomic, environmental, and evolutionary interruptions.Frontiers in microbiology · 2023Article
- Article
- Article
- Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies.Nature communications · 2022Article
- Contribution of the genomic and nutritional differentiation to the spatial distribution of bacterial colonies.Frontiers in microbiology · 2022Article
- Global coordination of the mutation and growth rates across the genetic and nutritional variety inFrontiers in microbiology · 2022Article
- Experimental Evolution Expands the Breadth of Adaptation to an Environmental Gradient Correlated With Genome Reduction.Frontiers in microbiology · 2022Article
- Towards an engineering theory of evolution.Nature communications · 2021Review
- Correlation between the spatial distribution and colony size was common for monogenetic bacteria in laboratory conditions.BMC microbiology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome reduction by removing dispensable genomic sequences in bacteria is commonly used in both fundamental and applied studies to determine the minimal genetic requirements for a living system or to develop highly efficient bioreactors. Nevertheless, whether and how the accumulative loss of dispensable genomic sequences disturbs bacterial growth remains unclear. To investigate the relationship between genome reduction and growth, a series of Escherichia coli strains carrying genomes reduced in a stepwise manner were used. Intensive growth analyses revealed that the accumulation of multiple genomic deletions caused decreases in the exponential growth rate and the saturated cell density in a deletion-length-dependent manner as well as gradual changes in the patterns of growth dynamics, regardless of the growth media. Accordingly, a perspective growth model linking genome evolution to genome engineering was proposed. This study provides the first demonstration of a quantitative connection between genomic sequence and bacterial growth, indicating that growth rate is potentially associated with dispensable genomic sequences.
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