ArticleeLife2016
Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct dopaminergic pathways.Nature neuroscience · 2025Article
- Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry.International journal of molecular sciences · 2022Review
- Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food.Nature communications · 2022Article
- Enhanced psychostimulant response, but not social avoidance, depends on GluA1 AMPA receptors in VTA dopamine neurons following intermittent social defeat stress in rats.The European journal of neuroscience · 2022Article
- Friend of the Devil: Negative Social Influences Driving Substance Use Disorders.Frontiers in behavioral neuroscience · 2022Review
- Social Determinants of Inter-Individual Variability and Vulnerability: The Role of Dopamine.Frontiers in behavioral neuroscience · 2022Review
- Stress Adaptation and the Brainstem with Focus on Corticotropin-Releasing Hormone.International journal of molecular sciences · 2021Review
- A proposed role for glucocorticoids in mediating dopamine-dependent cue-reward learning.Stress (Amsterdam, Netherlands) · 2021Article
- The neural, behavioral, and epidemiological underpinnings of comorbid alcohol use disorder and post-traumatic stress disorder.International review of neurobiology · 2021Article
- Dopamine Circuit Mechanisms of Addiction-Like Behaviors.Frontiers in neural circuits · 2021Review
- Parametric investigation of social place preference in adolescent mice.Behavioral neuroscience · 2020Article
- Can I Get a Witness? Using Vicarious Defeat Stress to Study Mood-Related Illnesses in Traditionally Understudied Populations.Biological psychiatry · 2020Review
- LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress.Journal of neurophysiology · 2020Article
- Inhibitory Plasticity: From Molecules to Computation and Beyond.International journal of molecular sciences · 2020Review
- A potential role for microglia in stress- and drug-induced plasticity in the nucleus accumbens: A mechanism for stress-induced vulnerability to substance use disorder.Neuroscience and biobehavioral reviews · 2019Review
- Early life stress alters transcriptomic patterning across reward circuitry in male and female mice.Nature communications · 2019Article
- Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF.Neurobiology of stress · 2018Review
- Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons.eLife · 2018Article
- Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning.Cell reports · 2018Article
- Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol.Annual review of pharmacology and toxicology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Enduring memories of sensory cues associated with drug intake drive addiction. It is well known that stressful experiences increase addiction vulnerability. However, it is not clear how repeated stress promotes learning of cue-drug associations, as repeated stress generally impairs learning and memory processes unrelated to stressful experiences. Here, we show that repeated social defeat stress in rats causes persistent enhancement of long-term potentiation (LTP) of NMDA receptor-mediated glutamatergic transmission in the ventral tegmental area (VTA). Protein kinase A-dependent increase in the potency of inositol 1,4,5-triphosphate-induced Ca(2+) signaling underlies LTP facilitation. Notably, defeated rats display enhanced learning of contextual cues paired with cocaine experience assessed using a conditioned place preference (CPP) paradigm. Enhancement of LTP in the VTA and cocaine CPP in behaving rats both require glucocorticoid receptor activation during defeat episodes. These findings suggest that enhanced glutamatergic plasticity in the VTA may contribute, at least partially, to increased addiction vulnerability following repeated stressful experiences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.