ArticleCurrent biology : CB2016
Neural Mechanisms Generating Orientation Selectivity in the Retina.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Cross-Frequency Couplings Reveal Mice Visual Cortex Selectivity to Grating Orientations.Brain and behavior · 2025Article
- Teneurin-2 and related proteins in reactive astrocytes afterFrontiers in neuroscience · 2025Article
- Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differential Expression Analysis Identifies Candidate Synaptogenic Molecules for Wiring Direction-Selective Circuits in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neural Circuits Underlying Multifeature Extraction in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distributed feature representations of natural stimuli across parallel retinal pathways.Nature communications · 2024Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina.PLoS biology · 2024Article
- Teneurin trans-axonal signaling prunes topographically missorted axons.Cell reports · 2023Article
- Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1.Nature communications · 2022Article
- Article
- To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly.Frontiers in neuroscience · 2022Review
- Spike-triggered Clustering for Retinal Ganglion Cell Classification.Experimental neurobiology · 2020Article
- New Features of Receptive Fields in Mouse Retina through Spike-triggered Covariance.Experimental neurobiology · 2020Article
- Article
- Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons.Cell · 2020Article
- Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period.Frontiers in behavioral neuroscience · 2020Article
- Predicting Grating Orientations With Cross-Frequency Coupling and Least Absolute Shrinkage and Selection Operator in V1 and V4 of Rhesus Monkeys.Frontiers in computational neuroscience · 2020Article
- Understanding the retinal basis of vision across species.Nature reviews. Neuroscience · 2020Review
Corrections and comments
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4 authors.
Funding
Abstract
The orientation of visual stimuli is a salient feature of visual scenes. In vertebrates, the first neural processing steps generating orientation selectivity take place in the retina. Here, we dissect an orientation-selective circuit in the larval zebrafish retina and describe its underlying synaptic, cellular, and molecular mechanisms. We genetically identify a class of amacrine cells (ACs) with elongated dendritic arbors that show orientation tuning. Both selective optogenetic ablation of ACs marked by the cell-adhesion molecule Teneurin-3 (Tenm3) and pharmacological interference with their function demonstrate that these cells are critical components for orientation selectivity in retinal ganglion cells (RGCs) by being a source of tuned GABAergic inhibition. Moreover, our morphological analyses reveal that Tenm3(+) ACs and orientation-selective RGCs co-stratify their dendrites in the inner plexiform layer, and that Tenm3(+) ACs require Tenm3 to acquire their correct dendritic stratification. Finally, we show that orientation tuning is present also among bipolar cell presynaptic terminals. Our results define a neural circuit underlying orientation selectivity in the vertebrate retina and characterize cellular and molecular requirements for its assembly.
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