ArticleOncotarget2016
Platelets as an indicator of vascular repair in elderly Japanese men.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Non-genetic biomarkers for ankylosing spondylitis: An umbrella review.Journal of clinical laboratory analysis · 2022Pooled it
- Subclinical hypothyroidism and height loss in relation to the status of thyroid cysts: a prospective study.Environmental health and preventive medicine · 2026Article
- Association between serum uric acid levels and cardio-ankle vascular index stratified by circulating level of CD34-positive cells among elderly Japanese men: a cross-sectional study.Scientific reports · 2024Article
- Association between underweight, serum albumin levels, and height loss in the Japanese male population: a retrospective study.Journal of physiological anthropology · 2024Article
- Platelet count and hypertension as indicators of height loss in the general population: A prospective study.PloS one · 2024Article
- Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population.Life (Basel, Switzerland) · 2023Article
- Mechanism underlying vascular remodeling in relation to circulating CD34-positive cells among older Japanese men.Scientific reports · 2022Article
- Vascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension.Scientific reports · 2022Article
- Influence of height on endothelial maintenance activity: a narrative review.Environmental health and preventive medicine · 2021Review
- Possible mechanisms underlying the association between human T-cell leukemia virus type 1 (HTLV-1) and hypertension in elderly Japanese population.Environmental health and preventive medicine · 2021Article
- Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study.Scientific reports · 2021Article
- Article
- Relationships of handgrip strength with the presence of cerebral microbleeds and platelet count in older Japanese adults.Oncotarget · 2020Article
- Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study.Scientific reports · 2020Article
- Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese.Environmental health and preventive medicine · 2019Article
- Article
- Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study.Clinical interventions in aging · 2019Article
- Common Injuries and Repair Mechanisms in the Endothelial Lining.Chinese medical journal · 2018Review
- Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study.Environmental health and preventive medicine · 2018Article
- Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men.Oncotarget · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and developing atherosclerosis). And because hypertension is known to be a strong vascular impairment factors, it should also influence the respective numbers of these factors. To clarify the clinical importance of platelets on vascular repair, we conducted a cross-sectional study of 567 Japanese men aged 60-69 who underwent an annual health check-up between 2013 and 2015. Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although platelet count did not significantly correlate with carotid intima media thickness (β = -0.05, p = 0.356), it did positively correlate significantly with the natural log of the number of circulating CD34-positive cells (β = 0.26, p < 0.001). In hypertensive subjects, a significant positive correlation was seen between platelets and intima media thickness (β = 0.19, p = 0.008), whereas no significant correlation was seen between platelet count and the natural log of the number of circulating CD34-positive cells (β = 0.11, p = 0.119). Our results indicate that platelet count is an indicator of vascular repair activity (endothelial repair and developing atherosclerosis). Additionally, hypertension might mask the beneficial effects of circulating CD34-positive cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.