Evidence map›Paper›PMID 27374076›Full record

ReviewMethods (San Diego, Calif.)2016

Use of fluorescent probes for ROS to tease apart Type I and Type II photochemical pathways in photodynamic therapy.

Maria Garcia-Diaz, Ying-Ying Huang, Michael R Hamblin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methods (San Diego, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Review
  6. Review
  7. Modulating the amphiphilic character of porphyrins with pH-activatable cationic centers and fluorocarbon chains to enhance antimicrobial photodynamic activity against Candida albicans.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  8. Review
  9. Article
  10. Current Perspectives on Photodynamic Therapy for Skin Diseases: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2026
    Review
  11. Review
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  13. Review
  14. Article
  15. Article
  16. Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Maria Garcia-DiazDepartment of Pharmacy, University of Copenhagen, Universitetsparken, 2, DK-2100, Copenhagen, Denmark.
Ying-Ying HuangWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address: Hamblin@helix.mgh.harvard.edu.
Harvard University · USUniversity of Copenhagen · DK

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Photodynamic therapy involves the excitation of a non-toxic dye by harmless visible light to produce a long-lived triplet state that can interact with molecular oxygen to produce reactive oxygen species (ROS), which can damage biomolecules and kill cells. ROS produced by electron transfer (Type 1) include superoxide, hydrogen peroxide and hydroxyl radical (HO), while singlet oxygen (

Indexed as

Electron TransportEnergy TransferBiosensing TechniquesFluorescent DyesHydrogen PeroxideHydroxyl RadicalLightPhotochemotherapyPorphyrinsReactive Oxygen SpeciesSinglet OxygenSuperoxidesTetrapyrrolesbacteriochlorinFluorescent DyesHydrogen PeroxideHydroxyl RadicalPorphyrinsReactive Oxygen SpeciesSinglet OxygenSuperoxidesTetrapyrrolesBacteriochlorinsFullerenesHydroxyl radicalHydroxyphenyl fluoresceinPhenothiazinium saltsPhotodynamic therapySinglet oxygenSinglet oxygen sensor green

Identifiers

PMID27374076
PMCPMC5075498
OpenAlexW2473006390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.