ArticleFood & nutrition research2016
Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols.
Article in Food & nutrition research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Skin Photoprotection and Anti-Aging Benefits of a Combination of Rosemary and Grapefruit Extracts: Evidence from In Vitro Models and Human Study.International journal of molecular sciences · 2025Trial
- Aesthetic Radiofrequency Associated withJournal of evidence-based integrative medicineTrial
- Photoprotective, Antioxidant and Anti-Inflammatory Effects of AgedFood science & nutrition · 2025Article
- Reversing Oxinflammation Associated with Glycative Stress and Formation of Advanced Glycation End Products with a Dietary Supplement Containing Rosemary Extract.The Journal of clinical and aesthetic dermatology · 2025Article
- A Single-center, Double-blinded, Randomized, Placebo-controlled Trial Evaluating the Safety and Efficacy of a Dietary Supplement Containing Rosemary Extract on Visible Facial Skin Quality.The Journal of clinical and aesthetic dermatology · 2025Article
- Reversing Glycation with a Dietary Supplement Containing Rosemary Extract.The Journal of clinical and aesthetic dermatology · 2025Review
- Natural solutions for glowing skin: spices.Frontiers in nutrition · 2025Review
- Exploring Phenolic Compounds in Crop By-Products for Cosmetic Efficacy.International journal of molecular sciences · 2024Review
- The Promising Role of Polyphenols in Skin Disorders.Molecules (Basel, Switzerland) · 2024Review
- Review
- Spontaneous Officinal Plants in the Cilento, Vallo di Diano and Alburni National Park: Tradition, Protection, Enhancement, and Recovery.Plants (Basel, Switzerland) · 2023Article
- A subcritical water extract of soil grownFrontiers in pharmacology · 2023Article
- Dietary Supplements and the Skin: Focus on Photoprotection and Antioxidant Activity-A Review.Nutrients · 2022Review
- Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals.Molecules (Basel, Switzerland) · 2021Review
- Review
- In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients fromPharmaceutics · 2021Article
- Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation.Antioxidants (Basel, Switzerland) · 2021Article
- Chemical Profile, Antioxidant, Anti-Proliferative, Anticoagulant and Mutagenic Effects of a Hydroalcoholic Extract of TuscanPlants (Basel, Switzerland) · 2021Article
- Antioxidant and reduced skin-ageing effects of a polyphenol-enriched dietary supplement in response to air pollution: a randomized, double-blind, placebo-controlled study.Food & nutrition research · 2021Article
- The Protective Effect of Rosmarinic Acid Against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts.Nutrients · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlant polyphenols have been found to be effective in preventing ultraviolet radiation (UVR)-induced skin alterations. A dietary approach based of these compounds could be a safe and effective method to provide a continuous adjunctive photoprotection measure. In a previous study, a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) extracts has exhibited potential photoprotective effects both in skin cell model and in a human pilot trial.
objectiveWe investigated the efficacy of a combination of rosemary (R. officinalis) and grapefruit (C. paradisi) in decreasing the individual susceptibility to UVR exposure (redness and lipoperoxides) and in improving skin wrinkledness and elasticity.
designA randomised, parallel group study was carried out on 90 subjects. Furthermore, a pilot, randomised, crossover study was carried out on five subjects. Female subjects having skin phototype from I to III and showing mild to moderate chrono- or photoageing clinical signs were enrolled in both studies. Skin redness (a* value of CIELab colour space) after UVB exposure to 1 minimal erythemal dose (MED) was assessed in the pilot study, while MED, lipoperoxides (malondialdehyde) skin content, wrinkle depth (image analysis), and skin elasticity (suction and elongation method) were measured in the main study.
resultsTreated subjects showed a decrease of the UVB- and UVA-induced skin alterations (decreased skin redness and lipoperoxides) and an improvement of skin wrinkledness and elasticity. No differences were found between the 100 and 250 mg extracts doses, indicating a plateau effect starting from 100 mg extracts dose. Some of the positive effects were noted as short as 2 weeks of product consumption.
conclusionsThe long-term oral intake of Nutroxsun™ can be considered to be a complementary nutrition strategy to avoid the negative effects of sun exposure. The putative mechanism for these effects is most likely to take place through the inhibition of UVR-induced reactive oxygen species and the concomitant inflammatory markers (lipoperoxides and cytokines) together with their direct action on intracellular signalling pathways.
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