ArticleScientific reports2016
Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Whole genome sequencing analysis of antibiotic resistant genes of Shigella species: A systematic review and meta-analysis.PloS one · 2025Pooled it
- The increasing antimicrobial resistance ofPathogens and global health · 2023Pooled it
- Whole genome sequencing and antimicrobial resistance among clinical isolates of Shigella sonnei in Addis Ababa, Ethiopia.PloS one · 2024Article
- Review
- Review
- Multiple Mechanisms Confer Resistance to Azithromycin inMicrobiology spectrum · 2022Article
- Immunization of Rabbits with a QuadrivalentmSphere · 2022Article
- Influence of Shigella flexneri 2a O Antigen Acetylation on Its Bacteriophage Sf6 Receptor Activity and Bacterial Interaction with Human Cells.Journal of bacteriology · 2020Article
- Emergence of multidrug-resistant Shigella species harboring extended-spectrum beta-lactamase genes in pediatric patients with diarrhea from southwest of Iran.Molecular biology reports · 2020Article
- The phenotypic and molecular characteristics of antimicrobial resistance of Salmonella enterica subsp. enterica serovar Typhimurium in Henan Province, China.BMC infectious diseases · 2020Article
- Shigella flexneri: an emerging pathogen.Folia microbiologica · 2020Review
- Antimicrobial resistance and genetic characterization of Shigella spp. in Shanxi Province, China, during 2006-2016.BMC microbiology · 2019Article
- Two novel mutations inAnnals of translational medicine · 2018Article
- Molecular characterization of fluoroquinolone and/or cephalosporin resistance in Shigella sonnei isolates from yaks.BMC veterinary research · 2018Article
- Out of Asia: the independent rise and global spread of fluoroquinolone-resistant Shigella.Microbial genomics · 2018Article
- Article
- Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum β-lactamase (ESBL).Annals of clinical microbiology and antimicrobials · 2017Article
- Newest data on fluoroquinolone resistance mechanism ofAntimicrobial resistance and infection control · 2017Article
- Article
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22 authors.
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Abstract
To conduct the first comprehensive analysis of Shigella flexneri serotype 4s, a novel serotype found in 2010, we identified 24 serotype 4s isolates from 1973 shigellosis cases in China (2002-2014). The isolates were characterized by single nucleotide polymorphism (SNP) phylogenetic analysis, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) to determine their genetic relatedness, and analysed further for their antimicrobial susceptibilities and antimicrobial resistance determinants. The PFGE and SNP phylogenetic analyses suggest that S. flexneri serotype 4s strains are derived from multiple serotypes, including two predominant serotypes in China: serotype X variant and serotype II. Three new sequence types were identified by MLST. All isolates were resistant to ticarcillin, ampicillin and tetracycline, with high-level resistance to third-generation cephalosporins. Notably, all the isolates were multidrug resistant (MDR), with the highest levels of resistance observed for eight antimicrobials classes. Most isolates contain various antimicrobial resistance determinants. In conclusion, we found that serotype 4s isolates have multiple evolutionary sources, diverse biochemical characteristics and genomes, and highly prevalent multidrug resistance and antimicrobial-resistant determinants. With few clinical treatment options, continuous monitoring and timely intervention against this emerging MDR serotype is essential. The possibility that serotype 4s will become the next predominant serotype exists.
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