ArticleScientific reports2016
A Combinatorial Algorithm for Microbial Consortia Synthetic Design.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- DyMMM-LEAPS: An ML-based framework for modulating evenness and stability in synthetic microbial communities.Biophysical journal · 2024Article
- Designing function-specific minimal microbiomes from large microbial communities.NPJ systems biology and applications · 2024Article
- Modeling approaches for probing cross-feeding interactions in the human gut microbiome.Computational and structural biotechnology journal · 2022Review
- Metabolic modelling approaches for describing and engineering microbial communities.Computational and structural biotechnology journal · 2021Review
- A Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites.Frontiers in bioengineering and biotechnology · 2021Article
- Modelling microbial communities: Harnessing consortia for biotechnological applications.Computational and structural biotechnology journal · 2021Review
- Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species.eLife · 2020Article
- The engineering of spatially linked microbial consortia - potential and perspectives.Current opinion in biotechnology · 2020Review
- From bag-of-genes to bag-of-genomes: metabolic modelling of communities in the era of metagenome-assembled genomes.Computational and structural biotechnology journal · 2020Review
- Microbial community design: methods, applications, and opportunities.Current opinion in biotechnology · 2019Review
- Engineering microbial consortia by division of labor.Microbial cell factories · 2019Review
- Human gut microbe co-cultures have greater potential than monocultures for food waste remediation to commodity chemicals.Scientific reports · 2018Article
- FLYCOP: metabolic modeling-based analysis and engineering microbial communities.Bioinformatics (Oxford, England) · 2018Article
- Scalable and exhaustive screening of metabolic functions carried out by microbial consortia.Bioinformatics (Oxford, England) · 2018Article
- Rhizosphere Microbiomes Modulated by Pre-crops Assisted Plants in Defense Against Plant-Parasitic Nematodes.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Synthetic biology has boomed since the early 2000s when it started being shown that it was possible to efficiently synthetize compounds of interest in a much more rapid and effective way by using other organisms than those naturally producing them. However, to thus engineer a single organism, often a microbe, to optimise one or a collection of metabolic tasks may lead to difficulties when attempting to obtain a production system that is efficient, or to avoid toxic effects for the recruited microorganism. The idea of using instead a microbial consortium has thus started being developed in the last decade. This was motivated by the fact that such consortia may perform more complicated functions than could single populations and be more robust to environmental fluctuations. Success is however not always guaranteed. In particular, establishing which consortium is best for the production of a given compound or set thereof remains a great challenge. This is the problem we address in this paper. We thus introduce an initial model and a method that enable to propose a consortium to synthetically produce compounds that are either exogenous to it, or are endogenous but where interaction among the species in the consortium could improve the production line.
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