ArticleDrug and alcohol dependence2016
Differential sensitivity to learning from positive and negative outcomes in cocaine users.
Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Undervaluing nondrug rewards or overvaluing cocaine? Cocaine demand relates to cocaine use severity more strongly than anhedonia in individuals with cocaine use disorder.Experimental and clinical psychopharmacology · 2025Trial
- The effects of acute oral naltrexone pretreatment on the abuse potential of intranasal methamphetamine, and the relationship between reward/punishment sensitivity and methamphetamine's effects.Behavioural pharmacology · 2022Trial
- Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation.The international journal of neuropsychopharmacology · 2021Trial
- Decisional incentive sensitivity is linked to contingency management outcome and striatal dopamine signaling in individuals with cocaine use disorder: a preliminary study.Addiction and substance abuse · 2026Article
- Parallel neuronal structural plasticity with memory trace formation in the orbitofrontal cortex.Nature communications · 2025Article
- Methodological considerations for behavioral studies relying on response time outcomes through online crowdsourcing platforms.Scientific reports · 2024Article
- Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand.Experimental and clinical psychopharmacology · 2023Article
- Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice.Nature communications · 2023Article
- Corrigendum to "Adolescent-onset vs. adult-onset cocaine use: Impact on cognitive functioning in animal models and opportunities for translation" [Pharmacol. Biochem. Behav. Volume 196, September (2020) 172994].Pharmacology, biochemistry, and behavior · 2021Article
- Contribution of alcohol- and cigarette-related cues to concurrent reinforcer choice in humans.Behavioural processes · 2020Article
- Baseline cocaine demand predicts contingency management treatment outcomes for cocaine-use disorder.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Leveraging crowdsourcing methods to collect qualitative data in addiction science: Narratives of non-medical prescription opioid, heroin, and fentanyl use.The International journal on drug policy · 2020Article
- Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder.Psychopharmacology · 2019Article
- Association of exercise with smoking-related symptomatology, smoking behavior and impulsivity in men and women.Drug and alcohol dependence · 2018Article
- Unique prediction of cannabis use severity and behaviors by delay discounting and behavioral economic demand.Behavioural processes · 2017Article
- Impaired Feedback Processing for Symbolic Reward in Individuals with Internet Game Overuse.Frontiers in psychiatry · 2017Article
- Comparing exponential and exponentiated models of drug demand in cocaine users.Experimental and clinical psychopharmacology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAltered sensitivity to positive and negative outcomes may be linked to the maladaptive choices characteristic of substance use disorders. Few studies have determined the distinct roles that positive and negative outcomes play in stimulus-response learning in cocaine users. The purpose of the present study was to investigate sensitivity to learning from positive and negative outcomes on a probabilistic learning task in cocaine users employing human laboratory and crowdsourcing techniques.
methodsIndividuals who reported cocaine use were recruited for a laboratory study (Experiment 1) or an online study on Amazon.com's Mechanical Turk (mTurk) (Experiment 2). All participants completed a feedback-based probabilistic learning task in which images were classified into categories (A versus B). Positive and negative outcomes were provided in a probabilistic manner on separate trials. Proportion of optimal responses and response times were recorded.
resultsActive cocaine users were less sensitive to learning from positive relative to negative outcomes. These effects were consistent across image type and session in the laboratory sample. Similarly, reduced sensitivity to learning from positive outcomes was observed in cocaine users on mTurk. Control participants did not show suboptimal performance following positive or negative outcomes.
conclusionsThis study extends the limited research on feedback-based learning in drug users by demonstrating reduced sensitivity to positive outcomes in cocaine users recruited in the human laboratory and online. Future studies on the clinical significance and mechanisms underlying this bias are needed to understand its relevance as a target for intervention development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.