ArticleCell reports2016
Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Characterization and functional analysis of BRCA1 and BRCA2 variants in a cohort of 100 unselected patients undergoing germline screening.Translational oncology · 2025Article
- Chemogenetic neuronal silencing decouples c-Jun activation from cell death in the temporal cortex.The European journal of neuroscience · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice.Biology of sex differences · 2024Article
- Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model.Scientific reports · 2022Article
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- Motivational and Valence-Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping.BMC biology · 2022Article
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
- Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Mild Traumatic Brain Injury Decreases Spatial Information Content and Reduces Place Field Stability of Hippocampal CA1 Neurons.Journal of neurotrauma · 2020Article
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- Article
- Dopamine receptor activity participates in hippocampal synaptic plasticity associated with novel object recognition.The European journal of neuroscience · 2017Article
- Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocampus. When entorhinal input to the perforant path was acutely silenced, hippocampal firing patterns became destabilized and underwent extensive remapping. We also found that spatial memory acquired prior to neural silencing was impaired by loss of input through the perforant path. Together, our experiments show that manipulation of entorhinal activity destabilizes spatial coding and disrupts spatial memory. Moreover, we introduce a chemogenetic model for non-invasive neuronal silencing that offers multiple advantages over existing strategies in this setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.