Evidence map›Paper›PMID 27372708›Full record

ArticleLa Radiologia medica2016

Evaluation of diffusion-weighted imaging (DWI) and MR spectroscopy (MRS) as early response biomarkers in cervical cancer patients.

Stefania Rizzo, Valentina Buscarino, Daniela Origgi, Paul Summers, Sara Raimondi, Roberta Lazzari, Fabio Landoni, Massimo Bellomi

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in La Radiologia medica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. The contribution of theEuropean radiology experimental · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stefania RizzoDepartment of Radiology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy. stefania.rizzo@ieo.it.
Valentina BuscarinoDepartment of Health Sciences, University of Milan, Via A.di Rudinì 8, 20142, Milan, Italy.
Daniela OriggiMedical Physics, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.
Paul SummersDepartment of Radiology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.
Sara RaimondiDivision of Epidemiology and Biostatistics, European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy.
Roberta LazzariDepartment of Radiotherapy, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.
Fabio LandoniDepartment of Gynaecology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.
Massimo BellomiDepartment of Radiology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo prospectively assess whether choline levels and Apparent Diffusion Coefficient (ADC) values within cervical cancers before, during, and after non-surgical therapy are predictive of tumour response. PATIENTS AND

methodsPatients undergoing MR examination for staging of cervical cancer, candidate for non-surgical therapy, were prospectively enrolled. According to the status at the end of therapies, patients were divided into responders and non-responders. The final outcome after a 5-year follow-up was classified as No Evidence of Disease (NED) or Progression of Disease (PD). Baseline values of mean ADC and Cho/H2O were compared between responders and non-responders, as well as between patients with NED and PD. The percent variation of ADC and Cho/H2O values over time was compared. P values <0.05 were considered significant.

results16 patients were included. There was no significant difference at baseline between responders (n = 12) and non-responders (n = 4), nor between NED (n = 11) PD patients (n = 5), in ADC values and Cho/H2O ratio. There was no significant difference in percent variation of ADC values and of Cho/H2O, comparing responders and non-responders. There was a significant increase in absolute values of ADC from the initial to mid-therapy MRI (p = 0.0001), while Cho/H2O was stable (p value: 0.61). In the four non-responders, the ADC increase was not significant (p value: 0.25), while it was significant in the 11 responders (p value: 0.001). Values of spectroscopy were stable in both responders and non-responders.

conclusionsHigh increases of ADC values from baseline to mid-therapy MR reflect response to therapies. There were no significant variations in choline/water ratios over time.

Indexed as

Diffusion Magnetic Resonance ImagingMagnetic Resonance SpectroscopyAdultAgedAged, 80 and overBiomarkersContrast MediaDisease ProgressionFemaleGadolinium DTPAHumansImage Interpretation, Computer-AssistedMiddle AgedNeoplasm StagingProspective StudiesTreatment OutcomeBiomarkersContrast MediaGadolinium DTPACervical cancerDWIMR spectroscopyResponse biomarkers

Identifiers

PMID27372708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.