ArticleJournal of Alzheimer's disease : JAD2016
Fine Particulate Matter, Residential Proximity to Major Roads, and Markers of Small Vessel Disease in a Memory Study Population.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Lifetime air pollution exposure, cognitive deficits, and brain imaging outcomes: A systematic review.Neurotoxicology · 2023Pooled it
- Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature.Environmental health perspectives · 2021Pooled it
- Geospatial Analysis of Environmental Atmospheric Risk Factors in Neurodegenerative Diseases: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Air Pollution and Dementia: A Systematic Review.Journal of Alzheimer's disease : JAD · 2019Pooled it
- Air pollution in relation to brain health indicators and global cognitive functioning in people with cardiovascular disorders along the heart-brain axis.Cerebral circulation - cognition and behavior · 2026Article
- Association of tailpipe-related and nontailpipe-related air pollution exposure with neuroimaging outcomes.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Association between residential proximity to major roadways and nonfatal cardiovascular disease in Chinese older adults: a nationwide study.Scientific reports · 2025Article
- Ambient air pollution exposure in relation to cerebral small vessel disease in Chinese population: A cranial magnetic resonance imaging-based study.Eco-Environment & Health · 2025Article
- Level of elderly-supportive infrastructure, fine particulate matter and cardiovascular disease hospitalisations: a time-stratified case-crossover study in Wuhan.Global health action · 2024Article
- Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study.Environmental health perspectives · 2023Article
- Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation.Journal of Korean medical science · 2023Article
- Recently decreased association of air pollution with cognitive impairment in a population-based aging cohort and in a mouse model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- The pathogenic effects of particulate matter on neurodegeneration: a review.Journal of biomedical science · 2022Review
- Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study.PLoS medicine · 2022Article
- Ambient Air Pollution and Long-Term Trajectories of Episodic Memory Decline among Older Women in the WHIMS-ECHO Cohort.Environmental health perspectives · 2021Article
- Long-Term Ambient Air Pollution Exposures and Brain Imaging Markers in Korean Adults: The Environmental Pollution-Induced Neurological EFfects (EPINEF) Study.Environmental health perspectives · 2020Article
- Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders.Pharmacology & therapeutics · 2020Review
- Association between exposure to air pollution and thalamus volume in adults: A cross-sectional study.PloS one · 2020Article
- Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease.Brain : a journal of neurology · 2020Article
- Brain Fog: Does Air Pollution Make Us Less Productive?Environmental health perspectives · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundLong-term exposure to ambient air pollution has been associated with impaired cognitive function and vascular disease in older adults, but little is known about these associations among people with concerns about memory loss.
objectiveTo examine associations between exposures to fine particulate matter and residential proximity to major roads and markers of small vessel disease.
methodsFrom 2004-2010, 236 participants in the Massachusetts Alzheimer's Disease Research Center Longitudinal Cohort participated in neuroimaging studies. Residential proximity to major roads and estimated 2003 residential annual average of fine particulate air pollution (PM2.5) were linked to measures of brain parenchymal fraction (BPF), white matter hyperintensities (WMH), and cerebral microbleeds. Associations were modeled using linear and logistic regression and adjusted for clinical and lifestyle factors.
resultsIn this population (median age [interquartile range] = 74 [12], 57% female) living in a region with median 2003 PM2.5 annual average below the current Environmental Protection Agency (EPA) standard, there were no associations between living closer to a major roadway or for a 2μg/m3 increment in PM2.5 and smaller BPF, greater WMH volume, or a higher odds of microbleeds. However, a 2μg/m3 increment in PM2.5 was associated with -0.19 (95% Confidence Interval (CI): -0.37, -0.005) lower natural log-transformed WMH volume. Other associations had wide confidence intervals.
conclusionsIn this population, where median 2003 estimated PM2.5 levels were below the current EPA standard, we observed no pattern of association between residential proximity to major roads or 2003 average PM2.5 and greater burden of small vessel disease or neurodegeneration.
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