ArticleJournal of neurology2016
Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence.
Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Inequalities and age-period-cohort effects of global and regional burden for interstitial lung disease and pulmonary sarcoidosis: based on Global Burden of Disease study 2021.Frontiers in medicine · 2025Article
- Age-period-cohort effect on motor neuron disease mortality in the United States, 2001-2020.Frontiers in neurology · 2025Article
- Estimated Familial Amyotrophic Lateral Sclerosis Proportion: A Literature Review and Meta-analysis.Neurology. Genetics · 2023Article
- Epidemiology of amyotrophic lateral sclerosis in the north east Tuscany in the 2018-2021 period.eNeurologicalSci · 2023Article
- Epidemiological, Clinical and Genetic Features of ALS in the Last Decade: A Prospective Population-Based Study in the Emilia Romagna Region of Italy.Biomedicines · 2022Article
- High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010-2020.Annals of clinical and translational neurology · 2022Article
- Future Incidence of Malignant Mesothelioma in South Korea: Updated Projection to 2038.International journal of environmental research and public health · 2021Article
- Age-Period-Cohort Analysis of Trends in Mental Health Mortality in India from 2001 to 2015.Community mental health journal · 2020Article
- Changing epidemiology of motor neurone disease in Scotland.Journal of neurology · 2019Article
- Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood.Journal of neurology · 2018Article
- Article
- Controlled population-based comparative study of USA and international adult [55-74] neurological deaths 1989-2014.Acta neurologica Scandinavica · 2017Article
- Secular Trends of Amyotrophic Lateral Sclerosis: The Piemonte and Valle d'Aosta Register.JAMA neurology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease with an unknown cause. Studies have reported that the incidence rate of ALS might be changing. As ALS is an age related disease, crude incidence could increase as population structure changes and overall life expectancy improves. Age-period-cohort (APC) models are frequently used to investigate trends in demographic rates such as incidence. Age-specific incidence rate for ALS from 1996 to 2014 were taken from a population-based ALS register in Ireland. To circumvent the well-known identifiability issue in APC models, we apply the method of Partial Least Squares Regression to separate the effects of Age, Period and Cohort on ALS incidence over time. This APC analysis shows no cohort effect and the initial signs of a period effect; increasing incidence of ALS in the most recently diagnosed group. As further years of data accrue to the Irish register it will become clear if this effect emerges as a strong trend in the incidence of ALS in Ireland and replication of these analyses in other populations will show if our findings on temporal patterns in ALS incidence are shared elsewhere.
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