ArticleInflammopharmacology2016
Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats.
Article in Inflammopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Exploring the Therapeutic Potential of Berberine and Tocopherol in Managing Diabetic Neuropathy: A Comprehensive Approach towards Alleviating Chronic Neuropathic Pain.Biomedicines · 2023Article
- Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats.Fundamental & clinical pharmacology · 2023Article
- Article
- Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Article
- A recent overview on the biological and pharmacological activities of ferulic acid.EXCLI journal · 2019Article
- Ferulic acid dimer as a non-opioid therapeutic for acute pain.Journal of pain research · 2018Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study focuses on the evaluation of phenolic compound ferulic acid (FA, 4-hydroxy-3-methoxycinnamic acid) in the chronic constriction injury (CCI) of sciatic nerve induced neuropathy in rats.
methodsThirty-six animals were randomly divided into six groups. Left sciatic nerve was exposed and ligated, animals in the control, standard, and test groups were treated orally with respective drugs for 21 days. Nociceptive thresholds (THERMAL hyperalgesia, mechanical hyperalgesia, and tactile allodynia) were assessed at 0 days and thereafter every 3 days till 3 weeks. Three weeks later, the sciatic nerve tissue homogenate was prepared and subjected for estimation of oxidative markers namely total protein, nitric oxide, lipid peroxidase, interleukins (IL-1β and IL-6).
resultsPregabalin (10 mg/kg, p.o.) and ferulic acid (10, 20, 30 mg/kg, p.o.), significantly and dose dependently, decreased all nociceptive thresholds (thermal hyperalgesia, mechanical hyperalgesia, and tactile allodynia) and biochemical markers (total protein, nitric oxide, lipid peroxidase, and interleukins).
conclusionIn conclusion, the anti-hyperalgesic effect of FA in rats receiving CCI might partly be attributed to its anti-oxidant and anti-inflammatory activity and is associated with the maintenance of neuropathic pain and could be useful as an adjuvant to conventional medicines.
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