ArticlePlant physiology2016
Oxygen Sensing via the Ethylene Response Transcription Factor RAP2.12 Affects Plant Metabolism and Performance under Both Normoxia and Hypoxia.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 108 citations in OpenAlex.
- Molecular and hormonal regulation of plant responses to waterlogging stress: From fundamental mechanisms to potential strategies for engineering crop tolerance.Plant communications · 2026Review
- Plastid-to-nucleus communication under hypoxia involves group VII ethylene response factors inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- GmAP2 enhances plant tolerance to aluminum toxicity and phosphorus deficiency in Arabidopsis.Plant cell reports · 2025Article
- The SCARECROW-LIKE transcription factor from Populus davidiana × P. bolleana simultaneously improved drought tolerance and plant growth through acetylation-dependent mechanisms.Plant biotechnology journal · 2025Article
- Microbial Enhancement of Plant Tolerance to Waterlogging: Mechanisms and Interplay with Biological Control of Pathogens.International journal of molecular sciences · 2025Review
- Deciphering Seed Deterioration: Molecular Insights and Priming Strategies for Revitalizing Aged Seeds.Plants (Basel, Switzerland) · 2025Review
- Loss-of-functional mutation in ANGUSTIFOLIA3 causes leucine hypersensitivity and hypoxia response during Arabidopsis thaliana seedling growth.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Metabolic strategies in hypoxic plants.Plant physiology · 2024Review
- The role of ethylene in the regulation of plant response mechanisms to waterlogging stress.Plant cell reports · 2024Review
- Genome-wide identification and analysis of ERF transcription factors related to abiotic stress responses in Nelumbo nucifera.BMC plant biology · 2024Article
- Recent progress in understanding the cellular and genetic basis of plant responses to low oxygen holds promise for developing flood-resilient crops.Journal of experimental botany · 2024Article
- Phosphatidic acid signaling and function in nuclei.Progress in lipid research · 2024Review
- Plant Life with and without Oxygen: A Metabolomics Approach.International journal of molecular sciences · 2023Review
- Physiological responses and Ethylene-Response AP2/ERF Factor expression in Indica rice seedlings subjected to submergence and osmotic stress.BMC plant biology · 2023Article
- Acquisition of hypoxia inducibility by oxygen sensing N-terminal cysteine oxidase in spermatophytes.Plant, cell & environment · 2023Article
- Bacterial ACC deaminase: Insights into enzymology, biochemistry, genetics, and potential role in amelioration of environmental stress in crop plants.Frontiers in microbiology · 2023Review
- Transcriptomic Analysis of Distal Parts of Roots Reveals Potentially Important Mechanisms Contributing to Limited Flooding Tolerance of Canola (International journal of molecular sciences · 2022Article
- The vacuolar H+/Ca transporter CAX1 participates in submergence and anoxia stress responses.Plant physiology · 2022Article
- Comparative Seeds Storage Transcriptome Analysis ofInternational journal of molecular sciences · 2022Article
- Bioinoculants as mitigators of multiple stresses: A ray of hope for agriculture in the darkness of climate change.Heliyon · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subgroup-VII-ethylene-response-factor (ERF-VII) transcription factors are involved in the regulation of hypoxic gene expression and regulated by proteasome-mediated proteolysis via the oxygen-dependent branch of the N-end-rule pathway. While research into ERF-VII mainly focused on their role to regulate anoxic gene expression, little is known on the impact of this oxygen-sensing system in regulating plant metabolism and growth. By comparing Arabidopsis (Arabidopsis thaliana) plants overexpressing N-end-rule-sensitive and insensitive forms of the ERF-VII-factor RAP2.12, we provide evidence that oxygen-dependent RAP2.12 stability regulates central metabolic processes to sustain growth, development, and anoxic resistance of plants. (1) Under normoxia, overexpression of N-end-rule-insensitive Δ13RAP2.12 led to increased activities of fermentative enzymes and increased accumulation of fermentation products, which were accompanied by decreased adenylate energy states and starch levels, and impaired plant growth and development, indicating a role of oxygen-regulated RAP2.12 degradation to prevent aerobic fermentation. (2) In Δ13RAP2.12-overexpressing plants, decreased carbohydrate reserves also led to a decrease in anoxic resistance, which was prevented by external Suc supply. (3) Overexpression of Δ13RAP2.12 led to decreased respiration rates, changes in the levels of tricarboxylic acid cycle intermediates, and accumulation of a large number of amino acids, including Ala and γ-amino butyric acid, indicating a role of oxygen-regulated RAP2.12 abundance in controlling the flux-modus of the tricarboxylic acid cycle. (4) The increase in amino acids was accompanied by increased levels of immune-regulatory metabolites. These results show that oxygen-sensing, mediating RAP2.12 degradation is indispensable to optimize metabolic performance, plant growth, and development under both normoxic and hypoxic conditions.
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