ArticleCerebellum (London, England)2017
Interhemispheric Connectivity Characterizes Cortical Reorganization in Motor-Related Networks After Cerebellar Lesions.
Article in Cerebellum (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- EEG-ECeG Coherence Mapping of Human Cerebro-cerebellar Projections: An Exploratory Study.Cerebellum (London, England) · 2026Article
- The cerebro-cerebellar system: Integrative roles in motor control, cognition, and neuropsychiatric disorders.IBRO neuroscience reports · 2026Review
- Brain changes in stroke patients during rehabilitation: a longitudinal study.Frontiers in neuroscience · 2025Article
- Bimanual coordinated motor skill learning in patients with a chronic cerebellar stroke.Experimental brain research · 2024Article
- A Narrative Review on Multi-Domain Instrumental Approaches to Evaluate Neuromotor Function in Rehabilitation.Healthcare (Basel, Switzerland) · 2023Review
- Train duration and inter-train interval determine the direction and intensity of high-frequency rTMS after-effects.Frontiers in neuroscience · 2023Article
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- Resting State EEG Directed Functional Connectivity Unveils Changes in Motor Network Organization in Subacute Stroke Patients After Rehabilitation.Frontiers in physiology · 2022Article
- A narrative review on non-invasive stimulation of the cerebellum in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Combined effect of repetitive transcranial magnetic stimulation and physical exercise on cortical plasticity.Neural regeneration research · 2020Review
- The Implementation of Predictions During Sequencing.Frontiers in cellular neuroscience · 2019Review
- Compressibility of High-Density EEG Signals in Stroke Patients.Sensors (Basel, Switzerland) · 2018Article
- Non-invasive Cerebellar Stimulation: a Promising Approach for Stroke Recovery?Cerebellum (London, England) · 2018Review
- Loss of brain inter-frequency hubs in Alzheimer's disease.Scientific reports · 2017Article
- Network interactions underlying mirror feedback in stroke: A dynamic causal modeling study.NeuroImage. Clinical · 2017Article
- Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis.NeuroImage. Clinical · 2017Article
- The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band.Frontiers in behavioral neuroscience · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although cerebellar-cortical interactions have been studied extensively in animal models and humans using modern neuroimaging techniques, the effects of cerebellar stroke and focal lesions on cerebral cortical processing remain unknown. In the present study, we analyzed the large-scale functional connectivity at the cortical level by combining high-density electroencephalography (EEG) and source imaging techniques to evaluate and quantify the compensatory reorganization of brain networks after cerebellar damage. The experimental protocol comprised a repetitive finger extension task by 10 patients with unilateral focal cerebellar lesions and 10 matched healthy controls. A graph theoretical approach was used to investigate the functional reorganization of cortical networks. Our patients, compared with controls, exhibited significant differences at global and local topological level of their brain networks. An abnormal rise in small-world network efficiency was observed in the gamma band (30-40 Hz) during execution of the task, paralleled by increased long-range connectivity between cortical hemispheres. Our findings show that a pervasive reorganization of the brain network is associated with cerebellar focal damage and support the idea that the cerebellum boosts or refines cortical functions. Clinically, these results suggest that cortical changes after cerebellar damage are achieved through an increase in the interactions between remote cortical areas and that rehabilitation should aim to reshape functional activation patterns. Future studies should determine whether these hypotheses are limited to motor tasks or if they also apply to cerebro-cerebellar dysfunction in general.
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