ArticleGenetics2016
The Evolutionary Fates of a Large Segmental Duplication in Mouse.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Highly polymorphic copy number variation in a segmental duplication in the mouse pseudoautosomal region even within inbred laboratory strains.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026Article
- An egg-sabotaging mechanism drives non-Mendelian transmission in mice.Current biology : CB · 2024Article
- An egg sabotaging mechanism drives non-Mendelian transmission in mice.bioRxiv : the preprint server for biology · 2024Article
- Identification of genomic loci regulating platelet plasminogen activator inhibitor-1 in mice.Journal of thrombosis and haemostasis : JTH · 2023Article
- Multiple genome viewer (MGV): a new tool for visualization and comparison of multiple annotated genomes.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Androgen-Binding Protein (Abp) Evolutionary History: Has Positive Selection Caused Fixation of Different Paralogs in Different Taxa of the Genus Mus?Genome biology and evolution · 2021Article
- Population Genomics of the House Mouse and the Brown Rat.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Mouse protein coding diversity: What's left to discover?PLoS genetics · 2019Review
- Gene conversion generates evolutionary novelty that fuels genetic conflicts.Current opinion in genetics & development · 2019Review
- Complex History and Differentiation Patterns of theGenetics · 2018Article
- Sequence and Structural Diversity of Mouse Y Chromosomes.Molecular biology and evolution · 2017Article
- Back to the Future: Multiparent Populations Provide the Key to Unlocking the Genetic Basis of Complex Traits.G3 (Bethesda, Md.) · 2017Article
- Back to the Future: Multiparent Populations Provide the Key to Unlocking the Genetic Basis of Complex Traits.Genetics · 2017Article
- Article
- Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.Genetics · 2017Article
- Genomes of the Mouse Collaborative Cross.Genetics · 2017Article
- Article
- Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection.G3 (Bethesda, Md.) · 2016Article
- Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers.G3 (Bethesda, Md.) · 2016Article
- search.bioPreprint: a discovery tool for cutting edge, preprint biomedical research articles.F1000Research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Gene duplication and loss are major sources of genetic polymorphism in populations, and are important forces shaping the evolution of genome content and organization. We have reconstructed the origin and history of a 127-kbp segmental duplication, R2d, in the house mouse (Mus musculus). R2d contains a single protein-coding gene, Cwc22 De novo assembly of both the ancestral (R2d1) and the derived (R2d2) copies reveals that they have been subject to nonallelic gene conversion events spanning tens of kilobases. R2d2 is also a hotspot for structural variation: its diploid copy number ranges from zero in the mouse reference genome to >80 in wild mice sampled from around the globe. Hemizygosity for high copy-number alleles of R2d2 is associated in cis with meiotic drive; suppression of meiotic crossovers; and copy-number instability, with a mutation rate in excess of 1 per 100 transmissions in some laboratory populations. Our results provide a striking example of allelic diversity generated by duplication and demonstrate the value of de novo assembly in a phylogenetic context for understanding the mutational processes affecting duplicate genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.