ArticleCerebral cortex (New York, N.Y. : 1991)2017
Volume Loss of the Nucleus Basalis of Meynert is Associated with Atrophy of Innervated Regions in Mild Cognitive Impairment.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Functional Subdivisions of Magnocellular Cell Groups in Human Basal Forebrain: Test-Retest Resting-State Study at Ultra-high Field, and Meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2019Pooled it
- Basal Forebrain Volume is Associated With Cortical Amyloid Burden in Cognitively Unimpaired Older Adults at Varying Genetic Risk for Alzheimer's Disease.The American journal of geriatric psychiatry. Open science, education, and practice · 2026Article
- Basal forebrain parvalbumin neuron dysfunction links network oscillation deficits to hippocampal pathology in Alzheimer's disease.Research square · 2026Article
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
- Article
- Functional architecture of the forebrain cholinergic system in rodents.Research square · 2024Article
- Combined in vivo MRI assessment of locus coeruleus and nucleus basalis of Meynert integrity in amnestic Alzheimer's disease, suspected-LATE and frontotemporal dementia.Alzheimer's research & therapy · 2024Article
- Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases.iScience · 2024Article
- Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI.AJNR. American journal of neuroradiology · 2023Article
- Structural (dys)connectivity associates with cholinergic cell density in Alzheimer's disease.Brain : a journal of neurology · 2022Article
- Identification of cholinergic centro-cingulate topography as main contributor to cognitive functioning in Parkinson's disease: Results from a data-driven approach.Frontiers in aging neuroscience · 2022Article
- The functional connectivity and neuropsychology underlying mental planning operations: data from the digital clock drawing test.Frontiers in aging neuroscience · 2022Article
- Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults.Frontiers in aging neuroscience · 2022Article
- Sex differences in the neuropathological hallmarks of Alzheimer's disease: focus on cognitively intact elderly individuals.Neuropathology and applied neurobiology · 2021Article
- Neurite Imaging Reveals Widespread Alterations in Gray and White Matter Neurite Morphology in Healthy Aging and Amnestic Mild Cognitive Impairment.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Article
- Meynert nucleus-related cortical thinning in Parkinson's disease with mild cognitive impairment.Quantitative imaging in medicine and surgery · 2021Article
- The Effect of theFrontiers in neurology · 2021Article
- Pre-Brodmann pioneers of cortical cytoarchitectonics I: Theodor Meynert, Vladimir Betz and William Bevan-Lewis.Brain structure & function · 2021Review
- Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer's Disease: Nexus of Cholinergic and Nerve Growth Factor Dysfunction.Current Alzheimer research · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Extensive research suggests that basal forebrain (BF) cholinergic neurons are selectively vulnerable to Alzheimer's disease (AD). However, it remains unknown whether volume loss of BF cholinergic compartments parallels structural changes of their innervated regions in prodromal AD. To this aim, we have correlated volume of each BF compartment with cortical thickness and hippocampus/amygdala volume in 106 healthy older (HO) adults and 106 amnestic mild cognitive impairment (aMCI) patients. Correlations were limited to regions affected by atrophy in aMCI. The volume of the nucleus basalis of Meynert (NBM/Ch4) was positively correlated with thickness of the temporal cortex in aMCI, and with volume of amygdala in HO and aMCI, separately. Volume of the medial septum/diagonal band of Broca (Ch1-Ch3) was also positively correlated with volume of the hippocampus within the 2 groups. Only correlations between the NBM and their innervated regions showed diagnostic value. Unlike men, aMCI women showed a stronger association between volume of the NBM and thickness of the temporal lobe when compared with HO women. Altogether, these results reveal, for the first time in humans, that atrophy of NBM is associated with structural changes of their innervated regions in prodromal AD, being this relationship more evident in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.