ArticleArchives of disease in childhood2016
Socioeconomic status inequalities in low-grade inflammation during childhood.
Article in Archives of disease in childhood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Socioeconomic status and inflammation: a meta-analysis.Molecular psychiatry · 2020Pooled it
- Socioeconomic status in childhood and C reactive protein in adulthood: a systematic review and meta-analysis.Journal of epidemiology and community health · 2017Pooled it
- The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing.Development and psychopathology · 2020Trial
- Externalizing trajectories predict elevated inflammation among adolescents exposed to early institutional rearing: A randomized clinical trial.Psychoneuroendocrinology · 2019Trial
- Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae.International journal of molecular sciences · 2024Review
- Epigenetic scores derived in saliva are associated with gestational age at birth.Clinical epigenetics · 2024Article
- Lingering Effects of Early Institutional Rearing and Cytomegalovirus Infection on the Natural Killer Cell Repertoire of Adopted Adolescents.Biomolecules · 2024Article
- C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Early Life SES, Childhood Trauma Exposures, and Cardiovascular Responses to Daily Life Stressors in Middle-aged Adults.International journal of behavioral medicine · 2023Article
- Low-quality protein modulates inflammatory markers and the response to lipopolysaccharide insult: the case of lysine.The British journal of nutrition · 2023Article
- Serving Individuals With Autism Spectrum Disorder in the Age of COVID-19: Special Considerations for Rural Families.Rural special education quarterly · 2023Article
- The Long Arm of childhood hypothesis and systematic low-grade inflammation: Evidence from parental education of older European adults.SSM - population health · 2023Article
- Understanding the Changing Landscape of Health Disparities in Chronic Liver Diseases and Liver Cancer.Gastro hep advances · 2023Article
- Maternal infections during pregnancy and child cognitive outcomes.BMC pregnancy and childbirth · 2022Article
- Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022Review
- Evaluating the association between socioeconomic position and cardiometabolic risk markers in young adulthood by different life course models.BMC public health · 2022Article
- Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences.International journal of environmental research and public health · 2022Review
- Longitudinal association of early childhood lead exposure and adolescent heart rate variability: influence of parental education.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2022Article
- Social support and C-reactive protein in a Québec population cohort of children and adolescents.PloS one · 2022Article
- Risk factors for the progression of trachomatous scarring in a cohort of women in a trachoma low endemic district in Tanzania.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFamily socioeconomic status (SES) is an important source of child health disparities in the USA. Chronic stress is one way SES may impact children's physiology with implications for later health inequalities. These processes may work differently across childhood due to differences in exposure and susceptibility to stressors at different ages. We assess associations between family SES and one biomarker of chronic stress exposure-low-grade inflammation detected by elevated C reactive protein (CRP)-and evaluate differences in the associations by child age.
methodsWe used nationally representative data from the National Health and Nutrition Examination Survey and Tobit regression models to estimate SES associations with CRP and the moderating effects of age for children age 2-18 years. Our sample was limited to CRP ≤10 mg/l to focus on low-grade inflammation (N=13 165).
resultsChildren whose parent had less than a high school degree had 35% higher CRP than those with a college graduate parent; and, poor children had 24% higher CRP than those with high family income, net of controls. When children's body mass index was accounted for, low education and poverty associations were reduced to 19% and 15%, respectively. Child age interactions were negative and significant for both parental education and family income.
conclusionsThis study provides new evidence that SES is associated with low-grade inflammation in children, and that these associations may be particularly strong during early and mid-childhood. Future research should further our understanding of stressors related to low family SES that may lead to immune system dysregulation during childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.