Evidence map›Paper›PMID 27371161›Full record

SynthesisNeuroscience and biobehavioral reviews2016

The effects of acute stress on core executive functions: A meta-analysis and comparison with cortisol.

Grant S Shields, Matthew A Sazma, Andrew P Yonelinas

3 registry-linked trialsAbstract readComparative StudyMeta-AnalysisReview
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 329 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
329citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03353441 nacompletednot on this mapstarted 2017, after this paper: background citation

Effects of Microencapsulated Sublingual Glycine (Bidicin) on Cognitive Performance in Healthy Men After an Acute Stressor - a Randomized, Partly Double-blind Placebo-controlled Clinical Trial

TypeinterventionalSponsorDaacroRan2017 to 2018Enrolled90ConditionsHealthy, Stress, Psychological, Cognitive ImpairmentArmsMicroencapsulated Sublingual Glycine (MSG), Placebo
NCT05172804 nacompletednot on this mapstarted 2020, after this paper: background citation

The Distinct Effects of Mind-Body Modalities on Health Outcomes in Nursing Students

TypeinterventionalSponsorJordan University of Science and TechnologyRan2020 to 2021Enrolled220ConditionsStress Reaction, Stress, Psychological, Stress, PhysiologicalArmsProgressive muscle relaxation, Guided Imagery, Mindfulness Meditation, Control group
NCT06199570 narecruitingnot on this mapstarted 2024, after this paper: background citation

Support for Cancer Patients Awaiting News (SCAN Study): Pilot Testing a Stress Management Program

TypeinterventionalSponsorHackensack Meridian HealthRan2024 to 2027Enrolled60ConditionsLung CancerArmsAdapted Stress Management Program, Enhanced Usual Care
3 · Its place in the literature

Who cites it

329 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Validity and effectiveness of interrogation techniques: A meta-analytic review.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2025
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  11. Prefrontal cortex stimulation prevents stress-induced HPA axis reactivity in people at familial risk of schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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269 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Grant S ShieldsDepartment of Psychology, University of California, Davis, USA. Electronic address: gsshields@ucdavis.edu.
Matthew A SazmaDepartment of Psychology, University of California, Davis, USA.
Andrew P YonelinasDepartment of Psychology, University of California, Davis, USA.

Funding

FUNCTIONAL PROPERTIES OF RECOGNITION MEMORYR01MH059352 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI YONELINAS, ANDREW P · 1999 to 2014
$3.9M
Plasticity, Perception, and the Medial Temporal LobesR01EY025999 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YONELINAS, ANDREW P · 2016 to 2022
$2.3M
NEI NIH HHS R01 EY025999NIMH NIH HHS R01 MH059352
6 · The paper itself

Abstract

Core executive functions such as working memory, inhibition, and cognitive flexibility are integral to daily life. A growing body of research has suggested that acute stress may impair core executive functions. However, there are a number of inconsistencies in the literature, leading to uncertainty about how or even if acute stress influences core executive functions. We addressed this by conducting a meta-analysis of acute stress effects on working memory, inhibition, and cognitive flexibility. We found that stress impaired working memory and cognitive flexibility, whereas it had nuanced effects on inhibition. Many of these effects were moderated by other variables, such as sex. In addition, we compared effects of acute stress on core executive functions to effects of cortisol administration and found some striking differences. Our findings indicate that stress works through mechanisms aside from or in addition to cortisol to produce a state characterized by more reactive processing of salient stimuli but greater control over actions. We conclude by highlighting some important future directions for stress and executive function research.

Indexed as

Executive FunctionHumansHydrocortisoneInhibition, PsychologicalMemory, Short-TermHydrocortisoneAcute stressCognitive controlCognitive flexibilityCortisolExecutive functionInhibitionInterference controlMeta-analysisResponse inhibitionSet shiftingWorking memory

Identifiers

PMID27371161
PMCPMC5003767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.