ArticleMedical & biological engineering & computing2017
Post-stimulation block of frog sciatic nerve by high-frequency (kHz) biphasic stimulation.
Article in Medical & biological engineering & computing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Efficacy and Safety of Kilohertz Frequency Alternating Current with Non-Invasive Electrodes for Treatment of Neuropathic Pain After Spinal Cord Injury: A Randomized, Single-Blind, Sham-Controlled Study.Journal of pain research · 2025Trial
- Effect of high-frequency alternating current transcutaneous stimulation over muscle strength: a controlled pilot study.Journal of neuroengineering and rehabilitation · 2018Trial
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Fascicle-selective kilohertz-frequency neural conduction block with longitudinal intrafascicular electrodes.Journal of neural engineering · 2025Article
- Cellular mechanisms underlying carry-over effects after magnetic stimulation.Scientific reports · 2024Article
- Model Analysis of Post-Stimulation Block of a Myelinated Axon by Direct Current.IEEE transactions on bio-medical engineering · 2023Article
- Mechanisms Underlying Poststimulation Block Induced by High-Frequency Biphasic Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency biphasic stimulation.Journal of neural engineering · 2022Article
- High-frequency stimulation induces axonal conduction block without generating initial action potentials.Journal of computational neuroscience · 2022Article
- HFAC Dose Repetition and Accumulation Leads to Progressively Longer Block Carryover Effect in Rat Sciatic Nerve.Frontiers in neuroscience · 2022Article
- Model Analysis of Post-Stimulation Effect on Axonal Conduction and Block.IEEE transactions on bio-medical engineering · 2021Article
- Pudendal Nerve Block by Low-Frequency (≤1 kHz) Biphasic Electrical Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Article
- Quantitative comparisons of block thresholds and onset responses for charge-balanced kilohertz frequency waveforms.Journal of neural engineering · 2020Article
- Poststimulation Block of Pudendal Nerve Conduction by High-Frequency (kHz) Biphasic Stimulation in Cats.Neuromodulation : journal of the International Neuromodulation Society · 2020Article
- Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig.Scientific reports · 2019Article
- Novel Neurostimulation of Autonomic Pelvic Nerves Overcomes Bladder-Sphincter Dyssynergia.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
This study determined if high-frequency biphasic stimulation can induce nerve conduction block that persists after the stimulation is terminated, i.e., post-stimulation block. The frog sciatic nerve-muscle preparation was used in the study. Muscle contraction force induced by low-frequency (0.5 Hz) nerve stimulation was recorded to indicate the occurrence and recovery of nerve block induced by the high-frequency (5 or 10 kHz) biphasic stimulation. Nerve block was observed during high-frequency stimulation and after termination of the stimulation. The recovery from post-stimulation block occurred in two distinct phases. During the first phase, the complete block induced during high-frequency stimulation was maintained. The average maximal duration for the first phase was 107 ± 50 s. During the second phase, the block gradually or abruptly reversed. The duration of both first and second phases was dependent on stimulation intensity and duration but not frequency. Stimulation of higher intensity (1.4-2 times block threshold) and longer duration (5 min) produced the longest period (249 ± 58 s) for a complete recovery. Post-stimulation block can be induced by high-frequency biphasic stimulation, which is important for future investigations of the blocking mechanisms and for optimizing the stimulation parameters or protocols in clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.