Evidence map›Paper›PMID 27370408›Full record

ArticleKidney international2016

Abnormalities in biomarkers of mineral and bone metabolism in kidney donors.

Bertram L Kasiske, Rajiv Kumar, Paul L Kimmel, Todd E Pesavento, Roberto S Kalil, Edward S Kraus, Hamid Rabb, Andrew M Posselt, Teresa L Anderson-Haag, Michael W Steffes and 4 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Guideline
  2. Donor medicine: An emerging field in nephrology.World journal of nephrology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Observational
  11. Chronic kidney disease as a cardiovascular risk factor: lessons from kidney donors.Journal of the American Society of Hypertension : JASH · 2018
    Review
  12. Review
  13. Review
  14. Article
  15. The effect of nephrectomy on Klotho, FGF-23 and bone metabolism.International urology and nephrology · 2017
    Observational
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Bertram L KasiskeDepartment of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USA. Electronic address: bkasiske@cdrg.org.
Rajiv KumarDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: rkumar@mayo.edu.
Paul L KimmelDivision of Kidney Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Todd E PesaventoDepartment of Medicine, Ohio State University, Columbus, Ohio, USA.
Roberto S KalilDepartment of Medicine, University of Iowa, Iowa City, Iowa, USA.
Edward S KrausDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Hamid RabbDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Andrew M PosseltDepartment of Surgery, University of California, San Francisco, San Francisco, California, USA.
Teresa L Anderson-HaagDepartment of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USA.
Michael W SteffesDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Ajay K IsraniDepartment of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USA; Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA.
Jon J SnyderMinneapolis Medical Research Foundation, Minneapolis, Minnesota, USA.
Ravinder J SinghDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Matthew R WeirDepartment of Medicine, University of Maryland, Baltimore, Maryland, USA.
Hennepin County Medical Center · USJohns Hopkins University · USMayo Clinic · USOrthopaedic Research Foundation · USNational Institute of Diabetes and Digestive and Kidney Diseases · USThe Ohio State University · USUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Maryland, Baltimore · USUniversity of Minnesota · US

Funding

Live Unrelated Kidney Donor & Sibling Follow-up StudyU01DK066013 · NIDDK · UNIVERSITY OF MINNESOTA · PI KASISKE, BERTRAM L · 2006 to 2016
$5.9M
Live Unrelated Kidney Donor &Sibling Follow-up StudyR01DK066013 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI KASISKE, BERTRAM L · 2005 to 2005
$558k
NIDDK NIH HHS R01 DK066013NIDDK NIH HHS U01 DK066013
6 · The paper itself

Abstract

Previous studies have suggested that kidney donors may have abnormalities of mineral and bone metabolism typically seen in chronic kidney disease. This may have important implications for the skeletal health of living kidney donors and for our understanding of the pathogenesis of long-term mineral and bone disorders in chronic kidney disease. In this prospective study, 182 of 203 kidney donors and 173 of 201 paired normal controls had markers of mineral and bone metabolism measured before and at 6 and 36 months after donation (ALTOLD Study). Donors had significantly higher serum concentrations of intact parathyroid hormone (24.6% and 19.5%) and fibroblast growth factor-23 (9.5% and 8.4%) at 6 and 36 months, respectively, as compared to healthy controls, and significantly reduced tubular phosphate reabsorption (-7.0% and -5.0%) and serum phosphate concentrations (-6.4% and -2.3%). Serum 1,25-dihydroxyvitamin D3 concentrations were significantly lower (-17.1% and -12.6%), while 25-hydroxyvitamin D (21.4% and 19.4%) concentrations were significantly higher in donors compared to controls. Moreover, significantly higher concentrations of the bone resorption markers, carboxyterminal cross-linking telopeptide of bone collagen (30.1% and 13.8%) and aminoterminal cross-linking telopeptide of bone collagen (14.2% and 13.0%), and the bone formation markers, osteocalcin (26.3% and 2.7%) and procollagen type I N-terminal propeptide (24.3% and 8.9%), were observed in donors. Thus, kidney donation alters serum markers of bone metabolism that could reflect impaired bone health. Additional long-term studies that include assessment of skeletal architecture and integrity are warranted in kidney donors.

Indexed as

Living DonorsAdultAlkaline PhosphataseBiomarkersBone and BonesBone ResorptionCalcitriolCollagen Type IFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsHumansKidney TransplantationMaleMiddle AgedMinerals25-hydroxyvitamin DAlkaline PhosphataseBiomarkersCalcitriolCollagen Type Icollagen type I trimeric cross-linked peptideFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsMineralsOsteocalcinParathyroid HormonePeptide FragmentsPeptidesPhosphatesProcollagenprocollagen Type I N-terminal peptideVitamin DFGF23hyperparathyroidismmineral metabolismparathyroid hormone

Identifiers

PMID27370408
PMCPMC5026566
OpenAlexW2461415670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.