ArticleThe British journal of psychiatry : the journal of mental science2016
Negative results in phase III trials of complex interventions: cause for concern or just good science?
Article in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Trial
- Trial
- Doing research in non-specialist mental health services for children and young people: lessons learnt from a process evaluation of the ICALM (Interpersonal Counselling for Adolescent Low Mood) feasibility randomised controlled trial.Pilot and feasibility studies · 2024Article
- A Meta-Research of Randomized Controlled Trials in the Field of Mental Health: Comparing Pharmacological to Non-Pharmacological Interventions from 1955 to 2020.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Article
- Putting music to trial: Consensus on key methodological challenges investigating music-based rehabilitation.Annals of the New York Academy of Sciences · 2022Review
- Feasibility and Acceptability of a Student-Led Lifestyle (Diet and Exercise) Intervention Within a Residential Rehabilitation Setting for People With Severe Mental Illness, GO HEART (Group Occupation, Health, Exercise And Rehabilitation Treatment).Frontiers in psychiatry · 2020Article
- Do adjunctive art therapies reduce symptomatology in schizophrenia? A meta-analysis.World journal of psychiatry · 2019Article
- From complex social interventions to interventions in complex social systems: Future directions and unresolved questions for intervention development and evaluation.Evaluation (London, England : 1995) · 2019Article
- A controlled trial of implementing a complex mental health intervention for carers of vulnerable young people living in out-of-home care: the ripple project.BMC psychiatry · 2016Article
Corrections and comments
- Comment on
Authors and funding
4 authors.
Funding
Abstract
Not all interventions that show promise in exploratory trials will be supported in phase III studies. But the high failure rate in recent trials of complex mental health interventions is a concern. Proper consideration of trial processes and greater use of adaptive trial designs could ensure better use of available resources.
Indexed as
Identifiers
27369475What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.