ArticleSchizophrenia bulletin2017
The Relationship of Intellectual Functioning and Cognitive Performance to Brain Structure in Schizophrenia.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Brain Morphological Characteristics of Cognitive Subgroups of Schizophrenia-Spectrum Disorders and Bipolar Disorder: A Systematic Review with Narrative Synthesis.Neuropsychology review · 2023Pooled it
- Characterising Demographic, Clinical and Functional Features of Cognitive Subgroups in Schizophrenia Spectrum Disorders: A Systematic Review.Neuropsychology review · 2022Pooled it
- Structural covariance networks in schizophrenia: A systematic review Part I.Schizophrenia research · 2022Pooled it
- A Meta-Analysis of Brain-Derived Neurotrophic Factor Effects on Brain Volume in Schizophrenia: Genotype and Serum Levels.Neuropsychobiology · 2021Pooled it
- Toward Generalizable and Clinically Useful Prediction of Occupational Functioning in Schizophrenia Using a Structure-Informed Representation of Cognition.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- From Micro Molecular to Functional Levels Through Macro Structures: Mediation of Structural Brain Changes on the Relationship Between Oxidative Stress and Cognition in Early Onset Psychosis.Schizophrenia bulletin open · 2026Article
- Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.BMC medicine · 2025Article
- Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases.Frontiers in neurology · 2024Review
- Effects of Substance Use and Antisocial Personality on Neuroimaging-Based Machine Learning Prediction of Schizophrenia.Schizophrenia bulletin · 2023Article
- Cerebellar Structure and Cognitive Ability in Psychosis.Biological psychiatry · 2022Article
- Clustering of cognitive subtypes in schizophrenia patients and their siblings: relationship with regional brain volumes.Schizophrenia (Heidelberg, Germany) · 2022Article
- Relationships between cognitive performance, clinical insight and regional brain volumes in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Altered Neuroanatomical Signatures of Patients With Treatment-Resistant Schizophrenia Compared to Patients With Early-Stage Schizophrenia and Healthy Controls.Frontiers in psychiatry · 2022Article
- Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis.Journal of clinical medicine · 2021Article
- Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity.NPJ schizophrenia · 2021Article
- Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review.Psychiatry and clinical neurosciences · 2021Article
- Latent Clinical-Anatomical Dimensions of Schizophrenia.Schizophrenia bulletin · 2020Article
- Corticolimbic brain anomalies are associated with cognitive subtypes in psychosis: A longitudinal study.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Background: Schizophrenia (SZ) is often characterized by cognitive and intellectual impairment. However, there is much heterogeneity across individuals, suggesting different trajectories of the illness. Recent findings have shown brain volume differences across subgroups of individuals with psychosis (SZ and bipolar disorder), such that those with intellectual and cognitive impairments presented evidence of early cerebral disruption, while those with cognitive but not intellectual impairments showed evidence of progressive brain abnormalities. Our aim was to investigate the relations of cognition and intellectual functioning with brain structure abnormalities in a sample of SZ compared to unaffected individuals. Methods: 92 individuals with SZ and 94 healthy controls part of the Northwestern University Schizophrenia Data and Software Tool (NUSDAST) underwent neuropsychological assessment and structural magnetic resonance imaging (MRI). Individuals with SZ were divided into subgroups according their estimated premorbid crystallized intellectual (ePMC-IQ) and cognitive performance. Brain volumes differences were investigated across groups. Results: SZ with ePMC-IQ and cognitive impairments had reduced total brain volume (TBV), intracranial volume (ICV), TBV corrected for ICV, and cortical gray matter volume, as well as reduced cortical thickness, and insula volumes. SZ with cognitive impairment but intact ePMC-IQ showed only reduced cortical gray matter volume and cortical thickness. Conclusions: These data provide additional evidence for heterogeneity in SZ. Impairments in cognition associated with reduced ePMC-IQ were related to evidence of broad brain structural alterations, including suggestion of early cerebral disruption. In contrast, impaired cognitive functioning in the context of more intact intellectual functioning was associated with cortical alterations that may reflect neurodegeneration.
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