ArticleSurgical endoscopy2016
Evaluation of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh in a porcine model of ventral hernia repair.
Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Biosynthetic meshes in contaminated fields: where are we now? A systematic review and meta-analysis in humans.Hernia : the journal of hernias and abdominal wall surgery · 2023Pooled it
- Prospective evaluation of poly-4-hydroxybutyrate mesh in CDC class I/high-risk ventral and incisional hernia repair: 18-month follow-up.Surgical endoscopy · 2018Trial
- Favorable one-year outcomes despite residual fascial tension after ventral hernia repair with transversus abdominis release.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- European Patient Views on the Use of a Bio-absorbable Internal Bra in Aesthetic Breast Surgery: Insights from 2,338 Women.Aesthetic plastic surgery · 2026Article
- Restoring Symmetry in Challenging Revision Breast Surgery: Outcomes of Pilot Study with Poly-4-Hydroxybutyrate Implant Construct.Plastic and reconstructive surgery. Global open · 2026Article
- How do we evaluate the remodeling and regeneration of absorbable meshes? Multi-dimensional evaluation parameters from multi-species.Hernia : the journal of hernias and abdominal wall surgery · 2026Review
- Health-related quality of life outcomes of bioabsorbable Phasix Mesh versus permanent synthetic mesh following open ventral hernia repair: a systematic literature review and narrative synthesis.Journal of abdominal wall surgery : JAWS · 2026Review
- Bio-resorbable poly-4-hydroxybutyrate (P4HB) mesh for abdominal wall reconstruction is effective in high-risk patients and contaminated abdomen.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Mesh removal and ventral hernia repair with long-term absorbable mesh in case of mesh infection.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Collagen Remodeling of Strattice™ Firm in a Nonhuman Primate Model of Abdominal Wall Repair.Bioengineering (Basel, Switzerland) · 2025Article
- Long-term outcome of prophylactic biosynthetic mesh reinforcement at the time of loop ileostomy reversal for colorectal cancer- results of a case-matched study.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Long-term results with biosynthetic absorbable P4HB mesh in ventral abdominal wall repair: a multicentre analysis.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Prophylactic Biosynthetic Retrorectus Mesh Placement During Stoma Reversal Reduces the Rate of Stoma Site Incisional Hernia.The Permanente journal · 2024Observational
- An established abdominal wall multidisciplinary team improves patient care and aids surgical decision making with complex ventral hernia patients.Annals of the Royal College of Surgeons of England · 2024Article
- A novel self-gripping long-term resorbable mesh providing temporary support for open primary ventral and incisional hernia.Journal of materials science. Materials in medicine · 2023Article
- Abdominal wall hernia repair: from prosthetic meshes to smart materials.Materials today. Bio · 2023Review
- Incisional hernia repair with a slowly absorbable P4HB mesh: what happens after the mesh disappears? A retrospective longitudinal clinical study.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- Article
- Fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for soft tissue repair and reconstruction: A scoping review.Frontiers in surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to evaluate the mechanical and histological properties of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh (Phasix™ ST) compared to partially absorbable (Ventralight™ ST), fully absorbable (Phasix™), and biologically derived (Strattice™) meshes in a porcine model of ventral hernia repair.
methodsBilateral abdominal surgical defects were created in twenty-four Yucatan pigs, repaired with intraperitoneal (Phasix™ ST, Ventralight™ ST) or retromuscular (Phasix™, Strattice™) mesh, and evaluated at 12 and 24 weeks (n = 6 mesh/group/time point).
resultsPrior to implantation, Strattice™ demonstrated significantly higher (p < 0.001) strength (636.6 ± 192.1 N) compared to Ventralight™ ST (324.3 ± 37.1 N), Phasix™ ST (206.9 ± 11.3 N), and Phasix™ (200.6 ± 25.2 N). At 12 and 24 weeks, mesh/repair strength was significantly greater than NAW (p < 0.01 in all cases), and no significant changes in strength were observed for any meshes between 12 and 24 weeks (p > 0.05). Phasix™ mesh/repair strength was significantly greater than Strattice™ (p < 0.001) at 12 and 24 weeks, and Ventralight™ ST mesh/repair strength was significantly greater than Phasix™ ST mesh (p < 0.05) at 24 weeks. At 12 and 24 weeks, Phasix™ ST and Ventralight™ ST were associated with mild inflammation and minimal-mild fibrosis/neovascularization, with no significant differences between groups. At both time points, Phasix™ was associated with minimal-mild inflammation/fibrosis and mild neovascularization. Strattice™ was associated with minimal inflammation/fibrosis, with minimal neovascularization at 12 weeks, which increased to mild by 24 weeks. Strattice™ exhibited significantly less neovascularization than Phasix™ at 12 weeks and significantly greater inflammation at 24 weeks due to remodeling.
conclusionsPhasix™ ST demonstrated mechanical and histological properties comparable to partially absorbable (Ventralight™ ST) and fully resorbable (Phasix™) meshes at 12 and 24 weeks in this model. Data also suggest that fully absorbable meshes with longer-term resorption profiles may provide improved mechanical and histological properties compared to biologically derived scaffolds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.