ArticleSocial cognitive and affective neuroscience2016
Amygdala functional connectivity as a longitudinal biomarker of symptom changes in generalized anxiety.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Article
- The role of amygdala reactivity in affective fluctuations across social contexts.Scientific reports · 2025Article
- The Importance of Including Psychophysiological Methods in Psychotherapy.Applied psychophysiology and biofeedback · 2025Review
- Prefrontal cortical circuits in anxiety and fear: an overview.Frontiers of medicine · 2022Review
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Article
- Reversed patterns of resting state functional connectivity for females vs. males in posttraumatic stress disorder.Neurobiology of stress · 2021Article
- Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group.Translational psychiatry · 2021Article
- Within-person increase in pathological worry predicts future depletion of unique executive functioning domains.Psychological medicine · 2021Article
- Out-of-step: brain-heart desynchronization in anxiety disorders.Molecular psychiatry · 2021Review
- Perseverative Cognition in the Positive Valence Systems: An Experimental and Ecological Investigation.Brain sciences · 2021Article
- Dynamic changes of amplitude of low-frequency fluctuations in patients with generalized anxiety disorder.Human brain mapping · 2020Article
- A mechanistic model for individualised treatment of anxiety disorders based on predictive neural biomarkers.Psychological medicine · 2020Review
- Threat bias and resting state functional connectivity of the amygdala and bed nucleus stria terminalis.Journal of psychiatric research · 2020Article
- Inflammation negatively correlates with amygdala-ventromedial prefrontal functional connectivity in association with anxiety in patients with depression: Preliminary results.Brain, behavior, and immunity · 2018Article
- Circadian challenge of astronauts' unconscious mind adapting to microgravity in space, estimated by heart rate variability.Scientific reports · 2018Article
- The verbal nature of worry in generalized anxiety: Insights from the brain.NeuroImage. Clinical · 2018Article
- Epileptic Seizures are Reduced by Autonomic Biofeedback Therapy Through Enhancement of Fronto-limbic Connectivity: A Controlled Trial and Neuroimaging Study.EBioMedicine · 2018Article
- Animal models in psychiatric research: The RDoC system as a new framework for endophenotype-oriented translational neuroscience.Neurobiology of stress · 2017Review
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Authors and funding
7 authors.
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Abstract
Generalized anxiety disorder (GAD) is characterized by excessive worry, autonomic dysregulation and functional amygdala dysconnectivity, yet these illness markers have rarely been considered together, nor their interrelationship tested longitudinally. We hypothesized that an individual's capacity for emotion regulation predicts longer-term changes in amygdala functional connectivity, supporting the modification of GAD core symptoms. Sixteen patients with GAD (14 women) and individually matched controls were studied at two time points separated by 1 year. Resting-state fMRI data and concurrent measurement of vagally mediated heart rate variability were obtained before and after the induction of perseverative cognition. A greater rise in levels of worry following the induction predicted a stronger reduction in connectivity between right amygdala and ventromedial prefrontal cortex, and enhanced coupling between left amygdala and ventral tegmental area at follow-up. Similarly, amplified physiological responses to the induction predicted increased connectivity between right amygdala and thalamus. Longitudinal shifts in a distinct set of functional connectivity scores were associated with concomitant changes in GAD symptomatology over the course of the year. Results highlight the prognostic value of indices of emotional dysregulation and emphasize the integral role of the amygdala as a critical hub in functional neural circuitry underlying the progression of GAD symptomatology.
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