ArticleBMC complementary and alternative medicine2016
Antibacterial constituents of Fructus Chebulae Immaturus and their mechanisms of action.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
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- Comprehensive Review on Fruit ofMolecules (Basel, Switzerland) · 2024Review
- Combinations ofAntibiotics (Basel, Switzerland) · 2024Article
- The therapeutic mechanism ofFrontiers in veterinary science · 2023Article
- Ethyl gallate isolated from phenol-enriched fraction ofFrontiers in pharmacology · 2023Article
- Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB PathwayMolecules (Basel, Switzerland) · 2022Article
- Mongolian medicine: History, development and existing problems.Chinese herbal medicines · 2022Review
- Preparation, Antibacterial Potential, and Antibacterial Components of Fermented Compound Chinese Medicine Feed Additives.Frontiers in veterinary science · 2022Article
- Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds.Future science OA · 2019Article
- Isolation and Identification of the Anti-Oxidant Constituents fromMolecules (Basel, Switzerland) · 2018Article
- Anti-methicillin-resistance Staphylococcus aureus (MRSA) compounds from Bauhinia kockiana Korth. And their mechanism of antibacterial activity.BMC complementary and alternative medicine · 2018Article
- Exploring the pharmacokinetic interactions between cisplatin and Triphala through in-vitro, in-vivo, and in-silico approaches - A pilot study to bridge modern medicine with Ayurveda.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo extract, purify, and identify the effective constituents of aqueous extract of Fructus Chebulae Immaturus, and analyze the bactericidal effects of total tannins.
methodsPreparative thin layer chromatography and semi-preparative high performance liquid chromatography were used to isolate and purify the total tannin fraction. (1)H- and (13)C- NMR spectroscopy were used to elucidate compound structures. The antibacterial activities of total tannins and ethyl gallate on Klebsiella pneumoniae (KP) and Staphylococcus aureus (SA) were determined through minimum inhibitory concentration and minimum bactericidal concentration assays. Their antibacterial mechanisms of action were explored by transmission electron microscopy and scanning electron microscopy.
resultsFive compounds were isolated: ellagic acid, ethyl gallate, arjugenin, β-sitosterol, and tri-n-butyl chebulate. Tri-n-butyl chebulate is a newly-reported compound. Total tannins and ethyl gallate both had favorable bactericidal effects against KP and SA.
conclusionIn vivo and in vitro pharmacodynamic experiment demonstrated that the effective components of Fructus Chebulae Immaturus possessed significant antibacterial effects, and were nontoxic and safe.
trial registrationNo results of a health care intervention on human participants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.