ArticleBreast cancer research : BCR2016
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.
Article in Breast cancer research : BCR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Meta-Analysis and Experimental Studies Reveal Mitotic Network Activity Index (MNAI) as Breast Cancer Metastasis and Treatment Biomarker.Life (Basel, Switzerland) · 2025Article
- The Approach to Multidisciplinary Oncologic Breast Care.Seminars in plastic surgery · 2025Review
- DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis.Scientific reports · 2024Article
- Pan-cancer evaluation of clinical value of mitotic network activity index (MNAI) and its predictive value for immunotherapy.Frontiers in oncology · 2023Article
- Identification of predictive factors of the degree of adherence to the Mediterranean diet through machine-learning techniques.PeerJ. Computer science · 2020Article
- FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis.Frontiers in oncology · 2020Review
- Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.Cancer cell international · 2020Article
- Upregulation of FOXP4 in breast cancer promotes migration and invasion through facilitating EMT.Cancer management and research · 2019Article
- Effects of RSF-1 on proliferation and apoptosis of breast cancer cells.Oncology letters · 2018Article
- Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.Nature communications · 2018Article
- Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.Breast cancer research : BCR · 2017Article
- Personalized Cancer Care: Risk Prediction, Early Diagnosis, Progression, and Therapy.Biomedicine hubArticle
Corrections and comments
- Erratum issued
Authors and funding
25 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundHigh mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer agents. With clinical trials of several of these experimental compounds underway, it is important to understand the molecular mechanisms that determine high mitotic activity, identify tumor subtypes that carry molecular aberrations that confer high mitotic activity, and to develop molecular markers that distinguish which tumors will be most responsive to mitotic apparatus inhibitors.
methodsWe identified a coordinately regulated mitotic apparatus network by analyzing gene expression profiles for 53 malignant and non-malignant human breast cancer cell lines and two separate primary breast tumor datasets. We defined the mitotic network activity index (MNAI) as the sum of the transcriptional levels of the 54 coordinately regulated mitotic apparatus genes. The effect of those genes on cell growth was evaluated by small interfering RNA (siRNA).
resultsHigh MNAI was enriched in basal-like breast tumors and was associated with reduced survival duration and preferential sensitivity to inhibitors of the mitotic apparatus proteins, polo-like kinase, centromere associated protein E and aurora kinase designated GSK462364, GSK923295 and GSK1070916, respectively. Co-amplification of regions of chromosomes 8q24, 10p15-p12, 12p13, and 17q24-q25 was associated with the transcriptional upregulation of this network of 54 mitotic apparatus genes, and we identify transcription factors that localize to these regions and putatively regulate mitotic activity. Knockdown of the mitotic network by siRNA identified 22 genes that might be considered as additional therapeutic targets for this clinically relevant patient subgroup.
conclusionsWe define a molecular signature which may guide therapeutic approaches for tumors with high mitotic network activity.
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