ArticleMedicine2016
Appendectomy correlates with increased risk of pyogenic liver abscess: A population-based cohort study in Taiwan.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Appendectomy as part of Ladd's procedure: a systematic review and survey analysis.Pediatric surgery international · 2023Pooled it
- Appendectomy and Risk of Nonyphoidal Salmonella Infection in Children.JAMA network open · 2026Article
- Incidence, Risk Factors, and Subsequent Health Outcomes of Pyogenic Liver Abscesses: A Scoping Review of Evidence From Population-Based Studies.Gastroenterology research and practice · 2025Review
- The association between history of appendectomy and gut microbiota composition: a follow-up cross-sectional study.Frontiers in microbiology · 2025Article
- Colonoscopy in the diagnosis and management of appendiceal disease.World journal of gastrointestinal endoscopy · 2024Article
- Appendectomy Is Associated With Alteration of Human Gut Bacterial and Fungal Communities.Frontiers in microbiology · 2021Article
- Patients with appendectomy are at increased risk of herpes zoster: real-world data in Taiwan.Internal and emergency medicine · 2019Article
- Women who had appendectomy have increased risk of systemic lupus erythematosus: a nationwide cohort study.Clinical rheumatology · 2018Article
- A comparison of pyogenic liver abscess in patients with or without diabetes: a retrospective study of 246 cases.BMC gastroenterology · 2018Article
- Observational
- Cryptogenic and non-cryptogenic liver abscess: A retrospective analysis of 178 cases revealed distinct characteristics.The Journal of international medical research · 2018Article
- Association between oral corticosteroid use and pyogenic liver abscesses in a case-control study.BioMedicine · 2018Article
- Impact of age at appendectomy on development of type 2 diabetes: A population-based cohort study.PloS one · 2018Article
- Population-based cohort study investigating the association between weight loss and pyogenic liver abscesses.BioMedicine · 2017Article
- Population-based cohort study examining the association between splenectomy and empyema in adults in Taiwan.BMJ open · 2017Article
- Recent upper gastrointestinal panendoscopy increases the risk of pyogenic liver abscess.World journal of gastroenterology · 2017Article
- Case-Control Study Examining the Association between Selective Serotonin Reuptake Inhibitors Use and Hepatocellular Carcinoma.Frontiers in pharmacology · 2017Article
- Zolpidem Administration and Risk of Hepatocellular Carcinoma: A Case-Control Study in Taiwan.Frontiers in pharmacology · 2017Article
- Herpes zoster correlates with pyogenic liver abscesses in Taiwan.BioMedicine · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known on the association between appendectomy and pyogenic liver abscess. The objective of this study was to investigate the association between appendectomy and the risk of pyogenic liver abscess in Taiwan.This population-based retrospective cohort study was conducted using the hospitalization dataset of the Taiwan National Health Insurance Program. There were 212,530 subjects age 20 to 84 years with newly diagnosed appendectomy as the appendectomy group since 1998 to 2010, and 850,099 randomly selected subjects without appendectomy as the nonappendectomy group. Both appendectomy and nonappendectomy groups were matched with sex, age, comorbidities, and index year of diagnosing appendectomy. The incidence of pyogenic liver abscess at the end of 2011 was estimated in both groups. The multivariable Cox proportional hazards regression model was applied to investigate the hazard ratio (HR) and 95% confidence interval (CI) for risk of pyogenic liver abscess associated with appendectomy and other comorbidities including alcoholism, biliary stone, chronic kidney disease, chronic liver diseases, and diabetes mellitus.The overall incidence of pyogenic liver abscess was 1.73-fold greater in the appendectomy group than that in the nonappendectomy group (3.85 vs 2.22 per 10,000 person-years, 95% CI 1.71, 1.76). The multivariable regression analysis disclosed that the adjusted HR of pyogenic liver abscess was 1.77 for the appendectomy group (95% CI 1.59, 1.97), when compared with the nonappendectomy group.Appendectomy is associated with increased hazard of pyogenic liver abscess. Further studies remain necessary to confirm our findings.
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