Evidence map›Paper›PMID 27367978›Full record

ArticleMedicine2016

Demographic and clinical characteristics related to cognitive decline in Alzheimer disease in China: A multicenter survey from 2011 to 2014.

Dantao Peng, Zhihong Shi, Jun Xu, Lu Shen, Shifu Xiao, Nan Zhang, Yi Li, Jinsong Jiao, Yan-Jiang Wang, Shuai Liu and 13 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 1 country.

Dantao PengaDepartment of Neurology, China-Japanese Friendship Hospital, Beijing bTianjin Key Laboratory of Cerebrovascular and of neurodegenerative diseases, Tianjin Dementia Institute cDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin dDepartment of Neurology, Northern Jiangsu Province Hospital, Affiliated to Yangzhou University, Yangzhou, Jiangsu Province eDepartment of Neurology, Xiangya Hospital, Central South University, Changsha fDepartment of Geriatrics, Shanghai Mental Health Center of Shanghai Jiaotong University School of Medicine, Shanghai gDepartment of neurology, General Hospital of Tianjin Medical University, Tianjin hDepartment of Neurology, Qilu Hospital, Shandong university, Shandong iDepartment of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing jDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University kFirst Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin lDepartment of Neurology, Beijing Hospital, Ministry of Health, Beijing mThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu Province nDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Zhihong Shi
Jun Xu
Lu Shen
Shifu Xiao
Nan Zhang
Yi Li
Jinsong Jiao
Yan-Jiang Wang
Shuai Liu
Meilin Zhang
Meng Wang
Shuling Liu
Yuying Zhou
Xiao Zhang
Xiao-Hua Gu
Ce-Ce Yang
Yu Wang
Bin Jiao
Beisha Tang
Jinhuan Wang
Tao Yu
Yong Ji
Tianjin Huanhu Hospital · CNCentral South University · CNShanghai Mental Health Center · CNTianjin Medical University · CNTianjin University of Traditional Chinese Medicine · CNArmy Medical University · CNBeijing Hospital · CNChina-Japan Friendship Hospital · CNDaping Hospital · CNNorthern Jiangsu People's Hospital · CNQilu Hospital of Shandong University · CNSecond Affiliated Hospital of Nanjing Medical University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer disease (AD) is the most frequent cause of dementia. AD diagnosis, progression, and treatment have not been analyzed nationwide in China. The primary aim of this study was to analyze demographic and clinical characteristics related to cognitive decline in AD patients treated at outpatient clinics in China.We performed a retrospective study of 1993 AD patients at 10 cognitive centers across 8 cities in China from March 2011 to October 2014. Of these, 891 patients were followed for more than 1 year.The mean age at diagnosis was 72.0 ± 10.0 years (range 38-96 years), and the mean age at onset of AD was 69.8 ± 9.5 years. Most patients (65.1%) had moderate to severe symptoms at the time of diagnosis, and mean Mini-Mental State Examination at diagnosis was 15.7 ± 7.7. AD patients showed significant cognitive decline at 12 months after diagnosis. Having more than 9 years of formal education was an independent risk factor related to rapid cognitive decline [odds ratio (OR) = 1.80; 95% confidence interval (95% CI): 1.11-2.91]. Early-onset AD patients experienced more rapid cognitive decline than late-onset patients (OR = 1.83; 95% CI: 1.09-3.06).Most AD patients in China had moderate to severe symptoms at the time of diagnosis and experienced significant cognitive decline within 1 year. Rapid cognitive decline in AD was related to having a higher educational level and younger age of onset.

Indexed as

AdultAgedAged, 80 and overAlzheimer DiseaseChinaCognitive DysfunctionDemographyFemaleHealth SurveysHumansMaleMiddle AgedRetrospective StudiesTime Factors

Identifiers

PMID27367978
PMCPMC4937892
OpenAlexW2467456284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.