ArticleJournal of pediatric gastroenterology and nutrition2016
Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group.
Article in Journal of pediatric gastroenterology and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Phenotype and Long-Term Outcome in Recurrent Paediatric Acute Liver Failure: Systematic Review and Individual Participant Data Analysis.Liver international : official journal of the International Association for the Study of the Liver · 2025Pooled it
- The incidence, frequency of late liver-related complications, and transplant likelihood in pediatric acute liver failure in Californian children.Hepatology communications · 2026Article
- Epidemiology and Outcomes of Hospitalizations for Children with Encephalopathy Associated with Severe Liver Dysfunction.Journal of pediatrics. Clinical practice · 2026Article
- Maternal Immunoglobulin Treatment of Gestational Alloimmune Liver Disease to Prevent Neonatal Liver Failure: A Single Center Case Series.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025Article
- Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Türkiye.Scientific reports · 2025Article
- Theta-Alpha Variability on EEG Is Associated With Acute Brain Injury in Children and Young Adults With Liver Failure.Neurology. Clinical practice · 2025Article
- Comparison of different anticoagulation methods in continuous renal replacement therapy for pediatric acute liver failure patients: a retrospective observational study.Frontiers in pediatrics · 2025Article
- Diagnosis and management of pediatric acute liver failure: consensus recommendations of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN).Hepatology international · 2024Review
- Continuous renal replacement therapy and therapeutic plasma exchange in pediatric liver failure.European journal of pediatrics · 2024Article
- Pediatric acute liver failure: Current perspective in etiology and management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Hepatic Encephalopathy in Children.Indian journal of pediatrics · 2024Review
- Improved mortality prediction for pediatric acute liver failure using dynamic prediction strategy.Journal of pediatric gastroenterology and nutrition · 2024Article
- Clinical Profile and Outcomes of Children with Acute Liver Failure in a Tertiary Care Center in South India: A Retrospective Study.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Live donor liver transplantation for pediatric acute liver failure: challenges and outcomes.Hepatology international · 2023Article
- Molecular Adsorbent Recirculating System for Acute Liver Failure in a New Pediatric-Based Extracorporeal Liver Support Program.Critical care explorations · 2023Article
- Pediatric Acute Liver Failure.Pediatric reports · 2023Article
- Heart rate variability is associated with encephalopathy and outcomes in pediatric acute liver failure.Pediatric research · 2023Observational
- Long-term outcomes of pediatric liver transplantation in acute liver failureWorld journal of transplantation · 2023Article
- Demographics, aetiology and outcome of paediatric acute liver failure in Singapore.Singapore medical journal · 2022Article
- The Role of Predictive Models in the Assessment of the Poor Outcomes in Pediatric Acute Liver Failure.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
objectivesHepatic encephalopathy (HE) is challenging to identify in children with acute liver failure and was not a requirement for enrollment into the Pediatric Acute Liver Failure Study Group (PALFSG). The outcomes of PALFSG participants presenting with and without HE are presented.
methodsPALFSG participants were classified based on daily assessment of HE during the first 7 days following study enrollment: group 1-never developed HE; group 2-no HE at enrollment with subsequent HE development; and group 3-HE at study enrollment. Clinical and biochemical parameters and outcomes of death, spontaneous recovery, or liver transplantation were compared between groups.
resultsData from 769 PALFSG (54% boys; median age 4.2 years; range 0-17.9 years) participants were analyzed, with 277 in group 1 (36%), 83 in group 2 (11%), and 409 in group 3 (53%). Mortality occurred in 11% of all participants and was highest among group 3 participants who demonstrated persistent grade III-IV HE (55%) or showed progression of HE (26%). Eleven (4%) group 1 participants died within 21 days of enrollment. Spontaneous recovery was highest in group 1 (79%) and lowest in group 2 (25%; P < 0.001).
conclusionsMortality 21 days after enrollment was highest in participants enrolled with severe HE (grades III or IV) or demonstrating HE progression. Four percent of participants without recorded clinical HE in the 7 days after enrollment, however, died within 21 days. Improved assessment of neurological injury and pediatric acute liver failure prognostication schema are needed.
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