Observational studyAmerican journal of respiratory and critical care medicine2016
Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma.
Observational study in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000575 (Childhood Asthma Management Program), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Childhood Asthma Management Program
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Association of LPCAT1-rs8352 genetic variant with susceptibility and severity of pediatric bronchial asthma: a case-control study.BMC pediatrics · 2025Article
- The chronological age at which small airway function starts to decline in a healthy Chinese population: a cross-sectional study.Frontiers in allergy · 2025Article
- Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health.Frontiers in public health · 2022Review
- COPD-associated miR-145-5p is downregulated in early-decline FEVThe Journal of allergy and clinical immunology · 2021Article
- Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome.Nature communications · 2020Article
- Lung functional development and asthma trajectories.Seminars in immunopathology · 2020Review
- Association ofAging · 2019Article
- Prospective observational study in patients with obstructive lung disease: NOVELTY design.ERJ open research · 2019Article
- The Linkage Between Low Pulmonary Function and Subclinical Cerebrovascular Lesion in Never-Smokers.Journal of atherosclerosis and thrombosis · 2018Article
- The Burden of Pediatric Asthma.Frontiers in pediatrics · 2018Review
- COPD: time to improve its taxonomy?ERJ open research · 2018Article
- Recent advances in understanding lung function development.F1000Research · 2017Review
- Review
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Authors and funding
38 authors at 13 institutions in 5 countries.
Funding
Abstract
rationalePatterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease.
objectivesTo determine the genetic underpinnings of lung function patterns in subjects with childhood asthma.
methodsWe performed a genome-wide association study of 581 non-Hispanic white individuals with asthma that were previously classified by patterns of lung function growth and decline (normal growth, normal growth with early decline, reduced growth, and reduced growth with early decline). The strongest association was also measured in two additional cohorts: a small asthma cohort and a large chronic obstructive pulmonary disease metaanalysis cohort. Interaction between the genomic region encompassing the most strongly associated single-nucleotide polymorphism and nearby genes was assessed by two chromosome conformation capture assays. MEASUREMENTS AND MAIN
resultsAn intergenic single-nucleotide polymorphism (rs4445257) on chromosome 8 was strongly associated with the normal growth with early decline pattern compared with all other pattern groups (P = 6.7 × 10
conclusionsEarly decline in lung function after normal growth is associated with a genetic polymorphism that may also protect against early decline in reduced growth groups. Clinical trial registered with www.clinicaltrials.gov (NCT00000575).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.