Evidence map›Paper›PMID 27367780›Full record

ReviewCurrent opinion in HIV and AIDS2016

HIV and ageing: improving quantity and quality of life.

Keri N Althoff, Mikaela Smit, Peter Reiss, Amy C Justice

Abstract readReview
In one paragraph

Review in Current opinion in HIV and AIDS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  5. Risk of Skin Cancers in Older Persons Living With HIV: A Systematic Review.The Journal of the Association of Nurses in AIDS Care : JANAC
    Pooled it
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keri N AlthoffaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAbDepartment of Infectious Disease Epidemiology, Imperial College London, London, UKcAcademic Medical Center, Department of Global Health, University of Amsterdam, Amsterdam Institute for Global Health and Development, and HIV Monitoring Foundation, Amsterdam, NetherlandsdYale University Schools of Medicine and Public Health and the Veterans Affairs Connecticut Healthcare System, New Haven, Connecticut, USA*Authors contributed equally.
Mikaela Smit
Peter Reiss
Amy C Justice

Funding

North American AIDS Cohorts on Collaboration and Design (NAACCORD)U01AI069918 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Keri Nicole Althoff, RICHARD Douglas MOORE · 2006 to 2026
$65.2M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Translational Research on Alcohol, Immunodeficiency, and Aging In COMpAAASU24AA022001 · NIAAA · YALE UNIVERSITY · PI BRANDT, CYNTHIA A. · 2012 to 2020
$3.2M
Immune function and the risk of cvd among HIV infected and uninfected veteransR01HL125032 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREIBERG, MATTHEW S, TRACY, RUSSELL P · 2014 to 2017
$2.8M
Challenging and Expanding Paradigms of Aging with HIVK01AI093197 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ALTHOFF, KERI NICOLE · 2011 to 2015
$646k
NHLBI NIH HHS R01 HL125032NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24 AA022001NIAID NIH HHS K01 AI093197NIAID NIH HHS U01 AI069918
6 · The paper itself

Abstract

purpose of reviewEvidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT

findingsModifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burden of harmful health behaviours, injury from HIV infection, HIV treatment toxicity and general burden of age-associated comorbidities. In turn, these factors contribute to geriatric syndromes including multimorbidity and polypharmacy, physiologic frailty, falls and fragility fractures and cognitive dysfunction, which further compromise the quality of life long before they lead to mortality. SUMMARY: Viral suppression of HIV with combination antiviral therapy has led to increasing longevity but has not enabled a complete return to health among ageing HIV-infected individuals (HIV+). As adults age with HIV, the role of HIV itself and associated inflammation, effects of exposure to antiretroviral agents, the high prevalence of modifiable risk factors for age-associated conditions (e.g. smoking), and the effects of other viral coinfections are all influencing the health trajectory of persons ageing with HIV. We must move from the simplistic notion of HIV becoming a 'chronic controllable illness' to understanding the continually evolving 'treated' history of HIV infection with the burden of age-associated conditions and geriatric syndromes in the context of an altered and ageing immune system.

Indexed as

Quality of LifeAgingHIV InfectionsHumans

Identifiers

PMID27367780
PMCPMC5084838

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.