ArticlePLoS computational biology2016
Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Cell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Trade-offs in concentration sensing in dynamic environments.Biophysical journal · 2024Article
- Thermotaxis in an apolar, non-neuronal animal.Journal of the Royal Society, Interface · 2023Article
- Single-cell directional sensing from just a few receptor binding events.Biophysical journal · 2023Article
- Coupling cell shape and velocity leads to oscillation and circling in keratocyte galvanotaxis.Biophysical journal · 2023Article
- Collective chemotaxis in a Voronoi model for confluent clusters.Biophysical journal · 2022Article
- The role of cell geometry and cell-cell communication in gradient sensing.PLoS computational biology · 2022Article
- Network Analysis Identifies Phase Transitions for Tumor With Interacting Cells.Frontiers in physiology · 2022Article
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Modelling chase-and-run migration in heterogeneous populations.Journal of mathematical biology · 2020Article
- Article
- Collective behaviors of Drosophila-derived retinal progenitors in controlled microenvironments.PloS one · 2019Article
- Minimal Network Topologies for Signal Processing during Collective Cell Chemotaxis.Biophysical journal · 2018Article
- Collective gradient sensing and chemotaxis: modeling and recent developments.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Review
- Analysis of Hierarchical Organization in Gene Expression Networks Reveals Underlying Principles of Collective Tumor Cell Dissemination and Metastatic Aggressiveness of Inflammatory Breast Cancer.Frontiers in oncology · 2018Article
- Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mechanisms of Cell Polarization.Current opinion in systems biology · 2017Article
- Inflammatory breast cancer: a model for investigating cluster-based dissemination.NPJ breast cancer · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Single eukaryotic cells commonly sense and follow chemical gradients, performing chemotaxis. Recent experiments and theories, however, show that even when single cells do not chemotax, clusters of cells may, if their interactions are regulated by the chemoattractant. We study this general mechanism of "collective guidance" computationally with models that integrate stochastic dynamics for individual cells with biochemical reactions within the cells, and diffusion of chemical signals between the cells. We show that if clusters of cells use the well-known local excitation, global inhibition (LEGI) mechanism to sense chemoattractant gradients, the speed of the cell cluster becomes non-monotonic in the cluster's size-clusters either larger or smaller than an optimal size will have lower speed. We argue that the cell cluster speed is a crucial readout of how the cluster processes chemotactic signals; both amplification and adaptation will alter the behavior of cluster speed as a function of size. We also show that, contrary to the assumptions of earlier theories, collective guidance does not require persistent cell-cell contacts and strong short range adhesion. If cell-cell adhesion is absent, and the cluster cohesion is instead provided by a co-attraction mechanism, e.g. chemotaxis toward a secreted molecule, collective guidance may still function. However, new behaviors, such as cluster rotation, may also appear in this case. Co-attraction and adaptation allow for collective guidance that is robust to varying chemoattractant concentrations while not requiring strong cell-cell adhesion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.