Evidence map›Paper›PMID 27367486›Full record

ArticleNeurourology and urodynamics2017

Somatic syndromes and chronic pain in women with overactive bladder.

W Stuart Reynolds, Stephen Mock, Xuechao Zhang, Melissa Kaufman, Alan Wein, Stephen Bruehl, Roger Dmochowski

Abstract read
In one paragraph

Article in Neurourology and urodynamics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

W Stuart ReynoldsDepartment of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Stephen MockDepartment of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Xuechao ZhangDepartment of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Melissa KaufmanDepartment of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Alan WeinDivision of Urology, Penn Medicine, Philadelphia, Pennsylvania.
Stephen BruehlDepartment of Anesthesia, Vanderbilt University Medical Center, Nashville, Tennessee.
Roger DmochowskiDepartment of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USUniversity of Pennsylvania Health System · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Afferent Hyperactivity Mechanisms in Overactive Bladder SyndromeK23DK103910 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI REYNOLDS, WILLIAM STUART · 2015 to 2019
$737k
NCATS NIH HHS UL1 TR000445NIDDK NIH HHS K23 DK103910
6 · The paper itself

Abstract

aimsMechanisms underlying pain perception and afferent hypersensitivity, such as central sensitization, may impact overactive bladder (OAB) symptoms. However, little is known about associations between OAB symptom severity, pain experience, and presence of comorbid chronic pain syndromes. This study examined relationships between OAB symptoms, somatic symptoms, and specific chronic pain conditions in which central sensitization is believed to play a primary role, in a community-based sample of adult women with OAB.

methodsWe recruited adult women with OAB to complete questionnaires assessing urinary symptoms, pain and somatic symptoms, and preexisting diagnoses of central sensitivity syndromes. We analyzed the effects of overall bodily pain intensity, general somatic symptoms, and diagnoses of central sensitivity syndromes on OAB symptom bother and health-related quality of life.

resultsOf the 116 women in this study, over half (54%) stated their urge to urinate was associated with pain, pressure, or discomfort. Participants reported a wide range of OAB symptoms and health-related quality of life. There was a significant, positive correlation between OAB symptoms and somatic symptoms as well as overall pain intensity. Only 7% of women met diagnostic criteria for fibromyalgia; yet these women demonstrated significantly increased OAB symptom burden and decreased OAB quality of life compared to those without fibromyalgia.

conclusionWomen with more severe OAB symptoms reported increased general somatic symptom burden and increased overall body pain intensity, especially women with fibromyalgia. These findings suggest that attributes of pain and co-morbidity with chronic pain conditions may impact the experience of OAB symptoms for many women. Neurourol. Urodynam. 36:1113-1118, 2017. © 2016 Wiley Periodicals, Inc.

Indexed as

AdultCentral Nervous System SensitizationChronic PainFemaleFibromyalgiaHumansMiddle AgedQuality of LifeSurveys and QuestionnairesSyndromeUrinary Bladder, Overactivecentral sensitizationfibromyalgiafunctional somatic disordersoveractive bladderurge urinary incontinence

Identifiers

PMID27367486
PMCPMC5203978
OpenAlexW2465980850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.