Trial reportAddiction (Abingdon, England)2016
Finding success in failure: using latent profile analysis to examine heterogeneity in psychosocial functioning among heavy drinkers following treatment.
Trial report in Addiction (Abingdon, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Reconsidering alcohol treatment non-responders: psychosocial functioning among heavy drinkers 3 years following treatment.Addiction (Abingdon, England) · 2021Trial
- Trait self-control predicts drinking patterns during treatment for alcohol use disorder and recovery up to three years following treatment.Addictive behaviors · 2019Trial
- Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Trial
- Abstinence and low risk drinking during treatment: Association with psychosocial functioning, alcohol use, and alcohol problems 3 years following treatment.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018Trial
- Alcohol-Related Nurse Care Management in Primary Care: A Randomized Clinical Trial.JAMA internal medicine · 2018Trial
- Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study.Alcoholism, clinical and experimental research · 2017Trial
- The search for an elusive cutoff remains: Problems of binary classification of heavy drinking as an endpoint for alcohol clinical trials.Drug and alcohol dependence · 2017Trial
- Exploring heterogeneity in recovery from substance use disorder following mindfulness-based relapse prevention: A latent profile analysis.Journal of substance use and addiction treatment · 2025Article
- Using digitally delivered measurement-based care in substance use disorder treatment: qualitative analysis of patients' perspectives.The American journal of drug and alcohol abuse · 2025Article
- 'Ageing with an alcohol problem is not what I envision': reclaiming agency in shaping personal ageing trajectory and recovery from alcohol problems.BMC geriatrics · 2023Article
- Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes.Drug and alcohol dependence · 2021Article
- What do clinicians want? Understanding frontline addiction treatment clinicians' preferences and priorities to improve the design of measurement-based care technology.Addiction science & clinical practice · 2021Article
- Factors associated with quality of life trajectories among inpatients treated for alcohol use disorders: A prospective cohort study.Addictive behaviors reports · 2020Article
- Can Alcohol Use Disorder Recovery Include Some Heavy Drinking? A Replication and Extension up to 9 Years Following Treatment.Alcoholism, clinical and experimental research · 2020Article
- Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.Alcoholism, clinical and experimental research · 2020Article
- Preresolution Drinking Problem Severity Profiles Associated with Stable Moderation Outcomes of Natural Recovery Attempts.Alcoholism, clinical and experimental research · 2020Article
- Epidemiology of Recovery From Alcohol Use Disorder.Alcohol research : current reviews · 2020Review
- Abstinence Not Required: Expanding the Definition of Recovery from Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2020Article
- Prevention, screening, and treatment for heavy drinking and alcohol use disorder.The lancet. Psychiatry · 2019Review
- Reduction in non-abstinent World Health Organization (WHO) drinking risk levels and drug use disorders: 3-year follow-up results in the US general population.Drug and alcohol dependence · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
aimsTo estimate differences in post-treatment psychosocial functioning among treatment 'failures' (i.e. heavy drinkers, defined as 4+/5+ drinks for women/men) from two large multi-site clinical trials and to compare these levels of functioning to those of the purported treatment 'successes' (i.e. non-heavy drinkers).
designSeparate latent profile analyses of data from two of the largest alcohol clinical trials conducted in the United States, COMBINE (Combined Pharmacotherapies and Behavioral Interventions) and Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity), comparing psychosocial outcomes across derived classes of heterogeneous treatment responders.
settingEleven US academic sites in COMBINE, 27 US treatment sites local to nine research sites in Project MATCH.
participantsA total of 962 individuals in COMBINE (69% male, 77% white, mean age: 44 years) treated January 2001 to January 2004 and 1528 individuals in Project MATCH (75% male, 80% white, mean age: 40 years) treated April 1991 to September 1994. MEASUREMENTS: In COMBINE, we analyzed health, quality of life, mental health symptoms and alcohol consequences 12 months post-baseline. In Project MATCH, we examined social functioning, mental health symptoms and alcohol consequences 15 months post-baseline.
findingsLatent profile analysis of measures of functioning in both samples supported a three-profile solution for the group of treatment 'failures', characterized by high-, average- and low-functioning individuals. The high-functioning treatment 'failures' generally performed better across measures of psychosocial functioning at follow-up than participants designated treatment 'successes' by virtue of being abstainers or light drinkers.
conclusionsCurrent United States Food and Drug Administration guidance to use heavy drinking as indicative of treatment 'failure' fails to take into account substantial psychosocial improvements made by individuals who continue occasionally to drink heavily post-treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.