ArticleJournal of biomedical optics2016
Infrared inhibition of embryonic hearts.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Thermal safety considerations for implantable micro-coil design.Journal of neural engineering · 2023Article
- Computational analysis of multichannel magnetothermal neural stimulation using magnetic resonator array.Biomedical engineering letters · 2023Article
- Optimizing thermal block length during infrared neural inhibition to minimize temperature thresholds.Journal of neural engineering · 2021Article
- Isotonic ion replacement can lower the threshold for selective infrared neural inhibition.Neurophotonics · 2021Article
- A Method for Recording the Bioelectrical Activity of Neural Axons upon Stimulation with Short Pulses of Infrared Laser Radiation.Sovremennye tekhnologii v meditsine · 2021Article
- Infrared inhibition impacts on locally initiated and propagating action potentials and the downstream synaptic transmission.Neurophotonics · 2020Article
- Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition.Lasers in surgery and medicine · 2020Article
- Infrared inhibition and waveform modulation of action potentials in the crayfish motor axon.Biomedical optics express · 2019Article
- Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study.Neurophotonics · 2019Article
- Influence of radiant exposure and repetition rate in infrared neural stimulation with near-infrared lasers.Lasers in medical science · 2019Article
- Thermal block of action potentials is primarily due to voltage-dependent potassium currents: a modeling study.Journal of neural engineering · 2019Article
- A review of optical pacing with infrared light.Journal of neural engineering · 2018Review
- Selective inhibition of small-diameter axons using infrared light.Scientific reports · 2017Article
- Ryanodine and IPNeurophotonics · 2017Article
- An infrared optical pacing system for screening cardiac electrophysiology in human cardiomyocytes.PloS one · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Infrared control is a new technique that uses pulsed infrared lasers to thermally alter electrical activity. Originally developed for nerves, we have applied this technology to embryonic hearts using a quail model, previously demonstrating infrared stimulation and, here, infrared inhibition. Infrared inhibition enables repeatable and reversible block, stopping cardiac contractions for several seconds. Normal beating resumes after the laser is turned off. The block can be spatially specific, affecting propagation on the ventricle or initiation on the atrium. Optical mapping showed that the block affects action potentials and not just calcium or contraction. Increased resting intracellular calcium was observed after a 30-s exposure to the inhibition laser, which likely resulted in reduced mechanical function. Further optimization of the laser illumination should reduce potential damage. Stopping cardiac contractions by disrupting electrical activity with infrared inhibition has the potential to be a powerful tool for studying the developing heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.