ArticleOncotarget2016
Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Altered Mitochondrial DNA Copy Number and Telomere Length in Patients with Substance Use Disorder: Correlation with Age, Sex, and Chronic Diseases.Biochemical genetics · 2025Article
- Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity.Obesity (Silver Spring, Md.) · 2024Article
- Blood-Based mtDNA Quantification Indicates Population-Specific Differences Associated with Alzheimer's Disease-Related Risk.Journal of Alzheimer's disease : JAD · 2024Article
- Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity.International journal of molecular sciences · 2023Review
- The prenatal environment and its influence on maternal and child mitochondrial DNA copy number and methylation: A review of the literature.Environmental research · 2023Review
- Telomere Length and Mitochondrial DNA Copy Number Variations in Patients with Obesity: Effect of Diet-Induced Weight Loss-A Pilot Study.Nutrients · 2022Article
- Diet Quality Scores Are Positively Associated with Whole Blood-Derived Mitochondrial DNA Copy Number in the Framingham Heart Study.The Journal of nutrition · 2022Article
- Reduced leukocyte mitochondrial copy number in metabolic syndrome and metabolically healthy obesity.Frontiers in endocrinology · 2022Article
- Prospective Associations of Early Pregnancy Metal Mixtures with Mitochondria DNA Copy Number and Telomere Length in Maternal and Cord Blood.Environmental health perspectives · 2021Article
- Blood mitochondrial DNA copy number: What are we counting?Mitochondrion · 2021Review
- Association between pre-diagnostic leukocyte mitochondrial DNA copy number and survival among colorectal cancer patients.Cancer epidemiology · 2020Article
- Insulinemic Potential of Lifestyle Is Inversely Associated with Leukocyte Mitochondrial DNA Copy Number in US White Adults.The Journal of nutrition · 2020Article
- Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number.Environment international · 2020Article
- Mitochondrial DNA Copy-Number Variation and Pancreatic Cancer Risk in the Prospective EPIC Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Breastfeeding predicts blood mitochondrial DNA content in adolescents.Scientific reports · 2020Article
- Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults.PloS one · 2020Article
- Pre-diagnostic leukocyte mitochondrial DNA copy number and colorectal cancer risk.Carcinogenesis · 2019Article
- Mitochondrial DNA methylation and copy number predict body composition in a young female population.Journal of translational medicine · 2019Article
- Article
- Pilot study of DNA methylation, molecular aging markers and measures of health and well-being in aging.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo examine the association between leukocyte mitochondrial DNA copy number (mtCN) and different anthropometric indices as well as weight changes; and to compare mtCN and telomere length with respect to their associations with BMI and age.
designPopulation based cohort study.
settingNurses' Health Study, an ongoing prospective cohort study of 121,700 nurses enrolled in 1976; in 1989-1990 a subset of 32,826 women provided blood samples.
participants1,700 disease-free US women from case-control studies nested within the Nurses' Health Study with mtCN and telomere length measured who also have anthropometric measurements.
main outcome measureRelative mtCN and telomere lengths in peripheral blood leukocytes measured by quantitative real time polymerase chain reaction and various anthropometric measurements data from initial questionnaire.
resultsLeukocyte mtCN was inversely associated with current weight (LS means Q1-Q4: 0.07, 0.04, 0.03, -0.17; P trend =0.002), waist size (LS means Q1-Q4: 0.06, 0.05, -0.04, -0.06; P trend = 0.04), BMI (LS means normal light, normal heavy, overweight, pre-obese, obese: 0.11, -0.01, -0.04, 0.04, -0.25; P trend<0.0001), and waist-hip ratio (WHR) (LS means Q1-Q4: 0.06, 0.08, -0.04, -0.06; P trend = 0.03). A one-unit decrease in mtCN z score was equivalent to approximately 3.5 pounds of weight gain for an adult of 5'10''. In addition, weight gain was bi-directionally and inversely associated with mtCN. Moreover, mtCN was strongly positively correlated with telomere length (LS means Q1-Q4: -0.02, 0.09, 0.11, 0.33; P trend <0.0001). MtCN was inversely associated with BMI even after adjusting for telomere length (P trend =0.003), while telomere length was not associated with BMI. On the other hand, telomere length was inversely associated with age after adjusting for mtCN (P trend =0.04), while mtCN was not associated with age.
conclusionsOur results provide compelling evidence for a potential bi-directional temporal relationship between mitochondrial-mediated oxidative stress-defense mechanisms and weight change.
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