Evidence map›Paper›PMID 27366992›Full record

ReviewCurrent opinion in pharmacology2016

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer.

Veronica Torrano, Felix Royo, Héctor Peinado, Ana Loizaga-Iriarte, Miguel Unda, Juan M Falcón-Perez, Arkaitz Carracedo

Abstract readReview
In one paragraph

Review in Current opinion in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Prospects of microRNAs as therapeutic biomarkers in non-small cell lung cancer.Medical oncology (Northwood, London, England) · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Small extracellular vesicles in cancer.Bioactive materials · 2021
    Review
  14. Article
  15. Review
  16. Review
  17. Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  18. Article
  19. Extracellular Vesicles in Chemoresistance.Sub-cellular biochemistry · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Veronica TorranoCIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain.
Felix RoyoCIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
Héctor PeinadoMicroenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
Ana Loizaga-IriarteDepartment of Urology, Basurto University Hospital, 48013 Bilbao, Spain.
Miguel UndaDepartment of Urology, Basurto University Hospital, 48013 Bilbao, Spain.
Juan M Falcón-PerezCIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain. Electronic address: jfalcon@cicbiogune.es.
Arkaitz CarracedoCIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), P.O. Box 644, E-48080 Bilbao, Spain. Electronic address: acarracedo@cicbiogune.es.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESHospital de Basurto · ESCIC bioGUNE · ESIkerbasque · ESSpanish National Cancer Research Centre · ES

Funding

Exosome-mediated Transfer of c-MET to Bone Marrow Progenitors Promotes MetastasisR01CA169416 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LYDEN, DAVID CHARLES, PEINADO, HECTOR · 2013 to 2017
$1.7M
European Research Council 336343NCI NIH HHS R01 CA169416
6 · The paper itself

Abstract

Normal and tumor cells shed vesicles to the environment. Within the large family of extracellular vesicles, exosomes and microvesicles have attracted much attention in the recent years. Their interest ranges from mediators of cancer progression, inflammation, immune regulation and metastatic niche regulation, to non-invasive biomarkers of disease. In this respect, the procedures to purify and analyze extracellular vesicles have quickly evolved and represent a source of variability for data integration in the field. In this review, we provide an updated view of the potential of exosomes and microvesicles as biomarkers and the available technologies for their isolation.

Indexed as

Biomarkers, TumorBiopsyCell-Derived MicroparticlesDisease ProgressionExosomesExtracellular VesiclesHumansInflammationNeoplasmsBiomarkers, Tumor

Identifiers

PMID27366992
PMCPMC4992611
OpenAlexW2465815646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.