Observational studyBioMed research international2016
Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis.
Observational study in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Efficacy of blood copeptin level for the prediction of mortality of adult patients with sepsis: a meta-analysis.Frontiers in medicine · 2025Pooled it
- Diagnostic Value of Copeptin and Growth Differentiation Factor-15 for Sepsis-Related Myocardial Injury.Infection and drug resistance · 2026Article
- Human neutrophil lipocalin, procalcitonin, c-reactive protein, and leucocyte count for prediction of bacterial sepsis in emergency department patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Pediatric sepsis diagnostic and prognostic biomarkers: pancreatic stone protein, copeptin, and apolipoprotein A-V.Pediatric research · 2023Article
- Apelin-13 as a Potential Biomarker in Critical Illness.Journal of clinical medicine · 2023Article
- Perspectives on the Immune System in Sepsis.Maedica · 2022Article
- Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care.Mikrochimica acta · 2022Review
- Activation of Vasopressin System During COVID-19 is Associated With Adverse Clinical Outcomes: An Observational Study.Journal of the Endocrine Society · 2021Article
- Review
- Biomarkers of sepsis: time for a reappraisal.Critical care (London, England) · 2020Review
- Serum Copeptin levels in the emergency department predict major clinical outcomes in adult trauma patients.BMC emergency medicine · 2020Observational
- Arginine Vasopressin and Posterior Reversible Encephalopathy Syndrome Pathophysiology: the Missing Link?Molecular neurobiology · 2019Review
- Prospective diagnostic and prognostic study of copeptin in suspected acute aortic syndromes.Scientific reports · 2018Article
- Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease?World journal of nephrology · 2018Review
- The Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin.Journal of biomarkers · 2017Article
- Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis.SpringerPlus · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnostic and prognostic usefulness of copeptin were evaluated in septic patients, as compared to procalcitonin assessment. In this single centre and observational study 105 patients were enrolled: 24 with sepsis, 25 with severe sepsis, 15 with septic shock, and 41 controls, divided in two subgroups (15 patients with gastrointestinal bleeding and 26 with suspected SIRS secondary to trauma, acute coronary syndrome, and pulmonary embolism). Biomarkers were determined at the first medical evaluation and thereafter 24, 48, and 72 hours after admission. Definitive diagnosis and in-hospital survival rates at 30 days were obtained through analysis of medical records. At entry, copeptin proved to be able to distinguish cases from controls and also sepsis group from septic shock group, while procalcitonin could distinguish also severe sepsis from septic shock group. Areas under the ROC curve for copeptin and procalcitonin were 0.845 and 0.861, respectively. Noteworthy, patients with copeptin concentrations higher than the threshold value (23.2 pmol/L), calculated from the ROC curve, at admission presented higher 30-day mortality. No significant differences were found in copeptin temporal profile among different subgroups. Copeptin showed promising diagnostic and prognostic role in the management of sepsis, together with its possible role in monitoring the response to treatment.
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