ArticleBioMed research international2016
Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig.
Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 84 citations in OpenAlex.
- Tryptophan supplementation in low-protein diets of sows during late gestation and lactation: Effects on sow performance and piglet growth.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Multi-omics elucidates the regulatory mechanisms of tryptophan in gut health of weaned piglets.Animal microbiome · 2026Article
- Dietary management of normoalbuminaemic canine chronic enteropathies.The Journal of small animal practice · 2026Review
- Kynurenine promotes porcine intestinal epithelial cell proliferation by activating the AHR-MST1-YAP1 axis.Journal of animal science and biotechnology · 2026Article
- Effects of dietary medium-chain fatty acid supplementation levels on growth performance, fecal score, energy, antioxidant, inflammatory status, and fecal metabolites of nursery pigs fed high-protein diets.Journal of animal science · 2026Article
- High indigestible dietary protein impairs growth and health status of nursery pigs with Salmonella Typhimurium more than with enterotoxigenic Escherichia coli F4 challenge.Journal of animal science · 2026Article
- The Role of Swine Gut Microbiota and Its Metabolites in Maintaining Intestinal Barrier Integrity and Mitigating Stress via the Gut-Brain Axis.Animals : an open access journal from MDPI · 2025Review
- Multi-Omics Insights into the Role of Dulcitol in Weaned Piglets' Growth Performance and Intestinal Health.Antioxidants (Basel, Switzerland) · 2025Article
- Functional gut variability drives metabolic and transcriptional features in neonatal piglets.NPJ science of food · 2025Article
- Orally Administered Zinc Gluconate Induces Tight Junctional Remodeling and Reduces Passive Transmucosal Permeability Across Human Intestine in a Patient-Based Study.International journal of molecular sciences · 2025Article
- Effect of Maternal Probiotic and Piglet Dietary Tryptophan Level on Performance and Piglet Intestinal Health Parameters Pre-Weaning.Microorganisms · 2025Article
- The potential mechanism of MicroRNA involvement in the regulation of muscle development in weaned piglets by tryptophan and its metabolites.BMC genomics · 2025Article
- Heat Stress in Growing-Finishing Pigs: Effects of Low Protein with Increased Crystalline Amino Acids on Growth, Gut Health, Antioxidant Status and Microbiome.Animals : an open access journal from MDPI · 2025Article
- Effects of medium-chain fatty acid supplementation levels in early nursery diets on growth performance, fecal score, gut permeability, energy status, and apparent total tract digestibility of weaning pigs.Translational animal science · 2025Article
- Dietary 5-hydroxytryptophan supplementation improves growth performance and intestinal health of weaned piglets.Porcine health management · 2024Article
- ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway.Cellular & molecular biology letters · 2024Article
- Tryptophan metabolism and piglet diarrhea: Where we stand and the challenges ahead.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers.Tissue barriers · 2024Article
- Low crude protein formulation with supplemental amino acids for its impacts on intestinal health and growth performance of growing-finishing pigs.Journal of animal science and biotechnology · 2024Article
- Amino acids in piglet diarrhea: Effects, mechanisms and insights.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tryptophan (Trp) plays an essential role in pig behavior and growth performances. However, little is known about Trp's effects on tight junction barrier and intestinal health in weaned pigs. In the present study, twenty-four (24) weaned pigs were randomly assigned to one of the three treatments with 8 piglets/treatments. The piglets were fed different amounts of L-tryptophan (L-Trp) as follows: 0.0%, 0.15, and 0.75%, respectively, named zero Trp (ZTS), low Trp (LTS), and high Trp (HTS), respectively. No significant differences were observed in average daily gain (ADG), average daily feed intake (ADFI), and gain: feed (G/F) ratio between the groups. After 21 days of the feeding trial, results showed that dietary Trp significantly increased (P < 0.05) crypt depth and significantly decreased (P < 0.05) villus height to crypt depth ratio (VH/CD) in the jejunum of pig fed HTS. In addition, pig fed HTS had higher (P < 0.05) serum diamine oxidase (DAO) and D-lactate. Furthermore, pig fed HTS significantly decreased mRNA expression of tight junction proteins occludin and ZO-1 but not claudin-1 in the jejunum. The number of intraepithelial lymphocytes and goblet cells were not significantly different (P > 0.05) between the groups. Collectively, these data suggest that dietary Trp supplementation at a certain level (0.75%) may negatively affect the small intestinal structure in weaned pig.
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