ReviewIndian journal of endocrinology and metabolism
Hypothyroidism and obesity: An intriguing link.
Review in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 277 citations in OpenAlex.
- Time Trends in Thyroid Hormone Changes Following Bariatric Surgery: A Systematic Review and Meta-Analysis.Obesity surgery · 2026Pooled it
- The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2019Pooled it
- Exploring the efficacy and safety of a novel standardized ashwagandha (Journal of psychopharmacology (Oxford, England) · 2023Trial
- Effect of metformin on thyroid function tests in patients with subclinical hypothyroidism: an open-label randomised controlled trial.Journal of endocrinological investigation · 2019Trial
- Endocrinological aspects of sarcopenic obesity.Annals of medicine · 2026Review
- Impact of Obesity on Individuals in Saudi Arabia: A Real-World Patient and Physician Survey.Advances in therapy · 2026Article
- Article
- Clinical utility of a novel index for predicting metabolic dysfunction-associated steatotic liver disease risk in children.European journal of pediatrics · 2026Article
- Concomitant Effect of Hypothyroidism with Obesity on Testicular and Sperm Function in Male ICR Mice: Involvement of TGFβ/SMAD Signaling.Cell biochemistry and biophysics · 2026Article
- Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam.Nature communications · 2026Article
- A Narrative Review of Weight Management Strategies: From Lifestyle Interventions to Emerging Pharmacotherapies.Journal of obesity · 2026Review
- Effect of metformin treatment on ovarian function in hypothyroid rats.Open veterinary journal · 2026Article
- Clinical and metabolic links between hypothyroidism and metabolic syndrome: a review.Frontiers in endocrinology · 2026Review
- Neuroendocrine-immune perturbations in metabolic disease: pathophysiological mechanisms underlying cognitive impairment.Frontiers in human neuroscience · 2026Review
- The clinical implications of the interaction between hypothyroidism and diabetes mellitus.Scientific reports · 2025Article
- Concurrent associations of glyphosate, dithiocarbamate fungicides, and PFAS with body fat composition and BMI in adolescents from agricultural communities.Environmental research · 2025Article
- Association between a history of hypothyroidism and incident chronic kidney disease and potential mediators: A cohort study with Mendelian randomization analysis.The Journal of international medical research · 2025Article
- Does Bariatric Surgery Impact Hypothyroidism and Vice Versa? Results of a Prospective Comparative Study.Obesity surgery · 2025Article
- Article
- Beyond GLP-1 Agonists: An Adaptive Ketogenic-Mediterranean Protocol to Counter Metabolic Adaptation in Obesity Management.Nutrients · 2025Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH) could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity. High leptin levels may play a role in the hyperthyrotropinemia of obesity and also increase susceptibility to thyroid autoimmunity and subsequent hypothyroidism. There is at most a modest effect of L-T4 treatment in overt hypothyroidism in inducing weight loss; benefit in subclinical hypothyroidism is not established with no data supporting thyroid hormone use in euthyroid obese patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.